Q05585 · MSRE_RABIT

Function

function

Membrane glycoproteins implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis. Two types of receptor subunits exist. These receptors mediate the endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcollagen trimer
Cellular Componentdendrite
Cellular Componentlow-density lipoprotein particle
Cellular Componentmembrane
Cellular Componentsynaptic cleft
Cellular Componentterminal bouton
Molecular Functionscavenger receptor activity
Biological Processreceptor-mediated endocytosis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Macrophage scavenger receptor types I and II
  • Alternative names
    • Macrophage acetylated LDL receptor I and II
  • CD Antigen Name
    • CD204

Gene names

    • Name
      MSR1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Lagomorpha > Leporidae > Oryctolagus

Accessions

  • Primary accession
    Q05585

Proteomes

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-50Cytoplasmic
Transmembrane51-73Helical; Signal-anchor for type II membrane protein
Topological domain74-454Extracellular

Keywords

PTM/Processing

Features

Showing features for chain, modified residue, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001816291-454Macrophage scavenger receptor types I and II
Modified residue27Phosphoserine
Glycosylation82N-linked (GlcNAc...) asparagine
Glycosylation102N-linked (GlcNAc...) asparagine
Glycosylation143N-linked (GlcNAc...) asparagine
Glycosylation184N-linked (GlcNAc...) asparagine
Glycosylation221N-linked (GlcNAc...) asparagine
Glycosylation249N-linked (GlcNAc...) asparagine
Glycosylation267N-linked (GlcNAc...) asparagine
Disulfide bond378↔442
Disulfide bond391↔452
Disulfide bond422↔432

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Homotrimer. Interacts with MYO18A.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, domain.

TypeIDPosition(s)Description
Region1-22Disordered
Region74-109Spacer
Coiled coil199-256
Region267-347Disordered
Domain273-344Collagen-like
Domain353-453SRCR

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q05585-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    454
  • Mass (Da)
    49,745
  • Last updated
    1996-10-01 v1
  • Checksum
    527A79692EA76429
MAQWDSFTDQQEDTDSCSESVKFDARSNTALLPPNPKNGPPLQEKLKSFKAALIALYLLVFAVLIPIIAIMAAQLLKWEMKNCTVGSINANSVSSSLLGRGNDSEHEVRFREVVMEHISKMEKRIQYISDTEENLVDSEHFQNFSVTTDQRFADVLLQLSTLVPTVQGHGNAVDEITRSLISLNTTLLDLHLYVETLNVKFQENTLKGQEEISKLKERVHNASAEIMSMKEEQVHLEQEIKREVKVLNNITNDLRLKDWEHSQTLRNITLIQGPPGPPGEKGDRGPTGESGPPGVPGPVGPPGLKGDRGSIGFPGSRGYPGQSGKTGRTGYPGPKGQKGEKGSGSILTPSATVRLVGGRGPHEGRVEILHNGQWGTVCDDHWELRAGQVVCRSLGYRGVKSVHKKAYFGQGTGPIWLNEVPCLGMESSIEECKIRQWGVRVCSHGEDAGVTCTL

Q05585-2

Features

Showing features for sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict106in Ref. 2; BAA02649
Alternative sequenceVSP_006233348-354in isoform II
Alternative sequenceVSP_006234355-454in isoform II

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L11693
EMBL· GenBank· DDBJ
AAA31402.1
EMBL· GenBank· DDBJ
mRNA
L11692
EMBL· GenBank· DDBJ
AAA31403.1
EMBL· GenBank· DDBJ
mRNA
D13381
EMBL· GenBank· DDBJ
BAA02649.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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