Q05533 · INM2_YEAST
- ProteinInositol monophosphatase 2
- GeneINM2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids292 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling.
Catalytic activity
- a myo-inositol phosphate + H2O = myo-inositol + phosphate
Cofactor
Activity regulation
Inhibited by Li+ and Na+.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
0.12 mM | inositol 1-phosphate |
Vmax | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|
16 μmol/min/mg | for inositol 1-phosphate |
Pathway
Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 75 | substrate | ||||
Sequence: E | ||||||
Binding site | 94 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 94 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 96 | Mg2+ 1 (UniProtKB | ChEBI) | ||||
Sequence: I | ||||||
Binding site | 96-99 | substrate | ||||
Sequence: IDGT | ||||||
Binding site | 97 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 231 | Mg2+ 2 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 231 | substrate | ||||
Sequence: D |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | inositol monophosphate 1-phosphatase activity | |
Molecular Function | inositol monophosphate 3-phosphatase activity | |
Molecular Function | inositol monophosphate 4-phosphatase activity | |
Molecular Function | metal ion binding | |
Biological Process | inositol biosynthetic process | |
Biological Process | inositol metabolic process | |
Biological Process | inositol phosphate catabolic process | |
Biological Process | phosphatidylinositol phosphate biosynthetic process | |
Biological Process | signal transduction |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInositol monophosphatase 2
- EC number
- Short namesIMP 2; IMPase 2
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ05533
- Secondary accessions
Proteomes
Organism-specific databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000245568 | 1-292 | Inositol monophosphatase 2 | |||
Sequence: MVLTRQVLEEVENTFIELLRSKIGPLVKSHAGTNFCSYDDKANGVDLVTALDKQIESIIKENLTAKYPSFKFIGEETYVKGVTKITNGPTFIVDPIDGTTNFIHGYPYSCTSLGLAEMGKPVVGVVFNPHLNQLFHASKGNGAFLNDQEIKVSKRPLILQKSLIALEGGSERTEGSQGNFDKKMNTYKNLLSESGAFVHGFRSAGSAAMNICYVASGMLDAYWEGGCWAWDVCAGWCILEEAGGIMVGGNCGEWNIPLDRRCYLAIRGGCESMEQKRFAESFWPHVAGELEY |
Proteomic databases
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length292
- Mass (Da)32,093
- Last updated1996-11-01 v1
- ChecksumCEA9D943F69E2082
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U51031 EMBL· GenBank· DDBJ | AAB64472.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY557746 EMBL· GenBank· DDBJ | AAS56072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA12127.1 EMBL· GenBank· DDBJ | Genomic DNA |