Q05533 · INM2_YEAST

Function

function

Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and involved in the inositol cycle of calcium signaling.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Activity regulation

Inhibited by Li+ and Na+.

Kinetics

KM SUBSTRATE pH TEMPERATURE[C] NOTES EVIDENCE
0.12 mMinositol 1-phosphate
Vmax pH TEMPERATURE[C] NOTES EVIDENCE
16 μmol/min/mgfor inositol 1-phosphate

Pathway

Polyol metabolism; myo-inositol biosynthesis; myo-inositol from D-glucose 6-phosphate: step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site75Mg2+ 1 (UniProtKB | ChEBI)
Binding site75substrate
Binding site94Mg2+ 1 (UniProtKB | ChEBI)
Binding site94Mg2+ 2 (UniProtKB | ChEBI)
Binding site96Mg2+ 1 (UniProtKB | ChEBI)
Binding site96-99substrate
Binding site97Mg2+ 2 (UniProtKB | ChEBI)
Binding site231Mg2+ 2 (UniProtKB | ChEBI)
Binding site231substrate

GO annotations

AspectTerm
Molecular Functioninositol monophosphate 1-phosphatase activity
Molecular Functioninositol monophosphate 3-phosphatase activity
Molecular Functioninositol monophosphate 4-phosphatase activity
Molecular Functionmetal ion binding
Biological Processinositol biosynthetic process
Biological Processinositol metabolic process
Biological Processinositol phosphate catabolic process
Biological Processphosphatidylinositol phosphate biosynthetic process
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Inositol monophosphatase 2
  • EC number
  • Short names
    IMP 2; IMPase 2
  • Alternative names
    • Inositol-1(or 4)-monophosphatase 2

Gene names

    • Name
      INM2
    • Synonyms
      IMP2
    • Ordered locus names
      YDR287W

Organism names

Accessions

  • Primary accession
    Q05533
  • Secondary accessions
    • D6VSR7

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002455681-292Inositol monophosphatase 2

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    292
  • Mass (Da)
    32,093
  • Last updated
    1996-11-01 v1
  • Checksum
    CEA9D943F69E2082
MVLTRQVLEEVENTFIELLRSKIGPLVKSHAGTNFCSYDDKANGVDLVTALDKQIESIIKENLTAKYPSFKFIGEETYVKGVTKITNGPTFIVDPIDGTTNFIHGYPYSCTSLGLAEMGKPVVGVVFNPHLNQLFHASKGNGAFLNDQEIKVSKRPLILQKSLIALEGGSERTEGSQGNFDKKMNTYKNLLSESGAFVHGFRSAGSAAMNICYVASGMLDAYWEGGCWAWDVCAGWCILEEAGGIMVGGNCGEWNIPLDRRCYLAIRGGCESMEQKRFAESFWPHVAGELEY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U51031
EMBL· GenBank· DDBJ
AAB64472.1
EMBL· GenBank· DDBJ
Genomic DNA
AY557746
EMBL· GenBank· DDBJ
AAS56072.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006938
EMBL· GenBank· DDBJ
DAA12127.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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