Q053V6 · SUCC_LEPBL

Function

function

Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; succinate from succinyl-CoA (ligase route): step 1/1.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site50ATP (UniProtKB | ChEBI)
Binding site57-59ATP (UniProtKB | ChEBI)
Binding site103ATP (UniProtKB | ChEBI)
Binding site106ATP (UniProtKB | ChEBI)
Binding site111ATP (UniProtKB | ChEBI)
Binding site203Mg2+ (UniProtKB | ChEBI)
Binding site217Mg2+ (UniProtKB | ChEBI)
Binding site268substrate; ligand shared with subunit alpha
Binding site325-327substrate; ligand shared with subunit alpha

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular Componentsuccinate-CoA ligase complex
Molecular FunctionATP binding
Molecular Functionmagnesium ion binding
Molecular Functionsuccinate-CoA ligase (ADP-forming) activity
Molecular Functionsuccinate-CoA ligase (GDP-forming) activity
Biological Processsuccinyl-CoA metabolic process
Biological Processtricarboxylic acid cycle

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Succinate--CoA ligase [ADP-forming] subunit beta
  • EC number
  • Alternative names
    • Succinyl-CoA synthetase subunit beta
      (SCS-beta
      )

Gene names

    • Name
      sucC
    • Ordered locus names
      LBL_0834

Organism names

Accessions

  • Primary accession
    Q053V6

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000821171-390Succinate--CoA ligase [ADP-forming] subunit beta

Interaction

Subunit

Heterotetramer of two alpha and two beta subunits.

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain9-248ATP-grasp

Sequence similarities

Belongs to the succinate/malate CoA ligase beta subunit family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    390
  • Mass (Da)
    41,982
  • Last updated
    2006-11-14 v1
  • Checksum
    068737440DF3532A
MKIHEYQAKEILRRHKANVPFGIVIDKKENASKAHDEVTSKTGGSVVVVKAQIHAGGRGKGGGVKVTKTKEDATAAVDKILGMQLITPQTGPEGKKVLKVYLEQGIDIAKEYYLSILLDRSIRKTILMASTEGGMEIEEVAETHPEKILKIAVDPGIGLQVNQARQLAFELGLPAESHKSFQSLVMAIYDAYIKEDASLLEINPLILTKQNEIIAGDCKIDLDENALYRHADNAAFRDITEEDPLEVQASEFNLNYVKLDGNIGCMVNGAGLAMATMDIVKLAGAEPANFLDVGGGANKTTVTNGFKIILGDPNVKGIFVNIFGGIVRCDMVAEGIIEAAKAVDLKVPLVVRLQGTNSELGREVLNKSGLKITGVDDLREAASTIAKLIK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000348
EMBL· GenBank· DDBJ
ABJ78389.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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