Q05213 · FOLD_THEAC
- ProteinBifunctional protein FolD
- GenefolD
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids276 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.
Catalytic activity
- (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADP+ = (6R)-5,10-methenyltetrahydrofolate + NADPH
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 157-159 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 182 | NADP+ (UniProtKB | ChEBI) | |||
Binding site | 223 | NADP+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methenyltetrahydrofolate cyclohydrolase activity | |
Molecular Function | methylenetetrahydrofolate dehydrogenase (NADP+) activity | |
Biological Process | L-histidine biosynthetic process | |
Biological Process | methionine biosynthetic process | |
Biological Process | purine nucleotide biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBifunctional protein FolD
Including 2 domains:
- Recommended nameMethylenetetrahydrofolate dehydrogenase
- EC number
- Recommended nameMethenyltetrahydrofolate cyclohydrolase
- EC number
Gene names
Organism names
- Strain
- Taxonomic lineageArchaea > Candidatus Thermoplasmatota > Thermoplasmata > Thermoplasmatales > Thermoplasmataceae > Thermoplasma
Accessions
- Primary accessionQ05213
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000199318 | 1-276 | Bifunctional protein FolD | ||
Proteomic databases
Interaction
Structure
Sequence
- Sequence statusComplete
- Length276
- Mass (Da)30,622
- Last updated2000-12-01 v2
- Checksum55DFA04ADBCBF907
Sequence caution
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL445065 EMBL· GenBank· DDBJ | CAC12027.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
X59788 EMBL· GenBank· DDBJ | CAA42451.1 EMBL· GenBank· DDBJ | Genomic DNA | Frameshift |