Q05129 · SCTB_ECO27

Function

function

Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (By similarity).
EspD and EspB are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (By similarity).
Necessary for intimate attachment to epithelial cells (PubMed:8393004).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componenthost cell membrane
Cellular Componentmembrane

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Type 3 secretion system translocon protein SctB
  • Short names
    T3SS translocon protein SctB
  • Alternative names
    • Protein EaeB

Gene names

    • Name
      sctB
    • Synonyms
      eaeB
      , espB
    • Ordered locus names
      E2348C_3934

Organism names

Accessions

  • Primary accession
    Q05129
  • Secondary accessions
    • B7UM92

Proteomes

Subcellular Location

Secreted
Cell surface
Host membrane
; Single-pass membrane protein
Note: Secreted via the type III secretion system (SPI-2 T3SS).

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane99-119Helical

Keywords

Phenotypes & Variants

Miscellaneous

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000868881-321Type 3 secretion system translocon protein SctB

Interaction

Subunit

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (By similarity).
This subunit is involved in the formation of a pore, called the translocon, in host membrane (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q05129espD B7UM932EBI-2530062, EBI-6414369

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the SctB/EspB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    321
  • Mass (Da)
    33,141
  • Last updated
    1995-11-01 v1
  • Checksum
    6D9CF59A0388AA39
MNTIDNNNAAIAVNSVLSSTTDSTSSTTTSTSSISSSLLTDGRVDISKLLLEVQKLLREMVTTLQDYLQKQLAQSYDIQKAVFESQNKAIDEKKAGATAALIGGAISSVLGILGSFAAINSATKGASDVAQQAASTSAKSIGTVSEASTKALAKASEGIADAADDAAGAMQQTIATAAKAASRTSGITDDVATSAQKASQVAEEAADAAQELAQKAGLLSRFTAAAGRISGSTPFIVVTSLAEGTKTLPTTISESVKSNHDINEQRAKSVENLQASNLDTYKQDVRRAQDDISSRLRDMTTTARDLTDLINRMGQAARLAG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z21555
EMBL· GenBank· DDBJ
CAA79733.1
EMBL· GenBank· DDBJ
Genomic DNA
AF022236
EMBL· GenBank· DDBJ
AAC38396.1
EMBL· GenBank· DDBJ
Genomic DNA
FM180568
EMBL· GenBank· DDBJ
CAS11482.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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