Q05090 · KLC_STRPU

Function

function

Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. The light chain may function in coupling of cargo to the heavy chain or in the modulation of its ATPase activity.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentkinesin complex
Cellular Componentmicrotubule
Molecular Functionkinesin binding
Biological Processmicrotubule-based movement

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Kinesin light chain
  • Short names
    KLC

Organism names

Accessions

  • Primary accession
    Q05090
  • Secondary accessions
    • Q04801
    • Q05088
    • Q05089

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002151001-686Kinesin light chain

Post-translational modification

Phosphorylation may modulate the process of mechanochemical coupling.

Keywords

Interaction

Subunit

Oligomeric complex composed of two heavy chains and two light chains.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region, coiled coil, repeat, compositional bias.

TypeIDPosition(s)Description
Region1-23Disordered
Coiled coil20-160
Region158-204Disordered
Repeat215-248TPR 1
Repeat257-290TPR 2
Repeat299-332TPR 3
Repeat341-374TPR 4
Repeat383-416TPR 5
Repeat472-505TPR 6
Region520-558Disordered
Region586-686Disordered
Compositional bias627-641Basic and acidic residues
Compositional bias648-686Polar residues

Domain

The light chain is composed of three structural domains: a large globular N-terminal domain which may be involved in binding to kinesin heavy chains, a central alpha-helical coiled-coil domain that mediates the light chain dimerization; and a small globular C-terminal which may play a role in regulating mechanochemical activity or attachment of kinesin to membrane-bound organelles.

Sequence similarities

Belongs to the kinesin light chain family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing. Additional isoforms seem to exist.

Q05090-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    KLC-3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    686
  • Mass (Da)
    76,517
  • Last updated
    1994-06-01 v1
  • Checksum
    603D71186CC0364B
MSGSKLSTPNNSGGGQGNLSQEQIITGTREVIKGLEQLKNEHNDILNSLYQSLKMLKKDTPGDSNLVEEKTDIIEKSLESLELGLGEAKVMMALGHHLNMVEAEKQKLRAQVRRLVQENTWLRDELAATQQKLQTSEQNLADLEVKYKHLEYMNSIKKYDEDRTPDEEASSSDPLDLGFPEDDDGGQADESYPQPQTGSGSVSAAAGGYEIPARLRTLHNLVIQYASQSRYEVAVPLCKQALEDLEKTSGHDHPDVATMLNILALVYRDQNKYKEAGNLLHDALAIREKTLGPDHPAVAATLNNLAVLYGKRGKYKEAEPLCKRALEIREKVLGKDHPDVAKQLNNLALLCQNQGKYEEVEWYYQRALEIYEKKLGPDDPNVAKTKNNLAAAYLKQGKYKAAETLYKQVLTRAHEREFGLSADDKDNKPIWMQAEEREEKGKFKDNAPYGDYGGWHKAAKVDSRSRSSPTVTTTLKNLGALYRRQGKYDAAEILEECAMKSRRNALDMVRETKVRELLGQDLSTDVPRSEAMAKERHHRRSSGTPRHGSTESVSYEKTDGSEEVSIGVAWKAKRKAKDRSRSIPAGYVEIPRSPPHVLVENGDGKLRRSGSLSKLRASVRRSSTKLLNKLKGRESDDDGGMKRASSMSVLPSRGNDESTPAPIQLSQRGRVGSHDNLSSRRQSGNF

Q05090-2

  • Name
    KLC-1
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q05090-3

  • Name
    KLC-2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q05090-4

  • Name
    KLC-4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 12 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A7M7T5H3A0A7M7T5H3_STRPU678
A0A7M7T4W8A0A7M7T4W8_STRPU691
A0A7M7PRB3A0A7M7PRB3_STRPU676
A0A7M7PRF1A0A7M7PRF1_STRPU672
A0A7M7PPL7A0A7M7PPL7_STRPU663
A0A7M7PTH0A0A7M7PTH0_STRPU666
A0A7M7PTB3A0A7M7PTB3_STRPU567
A0A7M7PT11A0A7M7PT11_STRPU565
A0A7M7PSA8A0A7M7PSA8_STRPU604
A0A7M7PRV8A0A7M7PRV8_STRPU576
A0A7M7PMZ9A0A7M7PMZ9_STRPU620
A0A7M7PNM2A0A7M7PNM2_STRPU700

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_002879441-451in isoform KLC-4
Alternative sequenceVSP_002880452-686in isoform KLC-4
Alternative sequenceVSP_002877564-572in isoform KLC-2
Alternative sequenceVSP_002878564-600in isoform KLC-1
Compositional bias627-641Basic and acidic residues
Compositional bias648-686Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L10235
EMBL· GenBank· DDBJ
AAA03059.1
EMBL· GenBank· DDBJ
mRNA
L10234
EMBL· GenBank· DDBJ
AAA03058.1
EMBL· GenBank· DDBJ
mRNA
L10233
EMBL· GenBank· DDBJ
AAA03057.1
EMBL· GenBank· DDBJ
mRNA
L08258
EMBL· GenBank· DDBJ
AAA03060.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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