Q04T55 · Q04T55_LEPBJ

Function

function

Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.

Catalytic activity

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide from N1-(5-phospho-D-ribosyl)glycinamide (10-formyl THF route): step 1/1.

Features

Showing features for binding site, active site, site.

120820406080100120140160180200
Type
IDPosition(s)Description
Binding site20-22N1-(5-phospho-beta-D-ribosyl)glycinamide (UniProtKB | ChEBI)
Binding site73(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site98-101(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Binding site115(6R)-10-formyltetrahydrofolate (UniProtKB | ChEBI)
Active site117Proton donor
Site153Raises pKa of active site His

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionphosphoribosylglycinamide formyltransferase activity
Biological Process'de novo' IMP biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoribosylglycinamide formyltransferase
  • EC number
  • Alternative names
    • 5'-phosphoribosylglycinamide transformylase
    • GAR transformylase
      (GART
      )

Gene names

    • Name
      purN
    • Ordered locus names
      LBJ_1330

Organism names

Accessions

  • Primary accession
    Q04T55

Proteomes

Subcellular Location

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain10-190Formyl transferase N-terminal

Sequence similarities

Belongs to the GART family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    208
  • Mass (Da)
    23,208
  • Last updated
    2006-11-14 v1
  • MD5 Checksum
    926D346BC8C48EF25DD1147174FAB9C4
MASPFTKPKKKIVFLTSGRGSNLKAVLQRIKVGKIRGVGSALICDNPDAKALEVAQEFKLPSHVFNFASFVDKSEYHKKLLNFLIELEPDLIVTAGYMKILKNQVIQAFPNRIINIHPSLLPAFPGLNAQKQAFEYGVKIAGCTAHFVDEGVDSGPVILQGVVKIEEGMSERDLTLEILKEEHKILPLAVQYFCEDRLKIHNRKVSIE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000350
EMBL· GenBank· DDBJ
ABJ75915.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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