Q04SI9 · ENO_LEPBJ

Function

function

Catalyzes the reversible conversion of 2-phosphoglycerate (2-PG) into phosphoenolpyruvate (PEP). It is essential for the degradation of carbohydrates via glycolysis.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds a second Mg2+ ion via substrate during catalysis.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 4/5.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site166(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Active site208Proton donor
Binding site245Mg2+ (UniProtKB | ChEBI)
Binding site291Mg2+ (UniProtKB | ChEBI)
Binding site318Mg2+ (UniProtKB | ChEBI)
Active site343Proton acceptor
Binding site343(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Binding site372(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Binding site373(2R)-2-phosphoglycerate (UniProtKB | ChEBI)
Binding site394(2R)-2-phosphoglycerate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componentphosphopyruvate hydratase complex
Molecular Functionmagnesium ion binding
Molecular Functionphosphopyruvate hydratase activity
Biological Processglycolytic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Enolase
  • EC number
  • Alternative names
    • 2-phospho-D-glycerate hydro-lyase
    • 2-phosphoglycerate dehydratase

Gene names

    • Name
      eno
    • Ordered locus names
      LBJ_1561

Organism names

Accessions

  • Primary accession
    Q04SI9

Proteomes

Subcellular Location

Cytoplasm
Secreted
Cell surface
Note: Fractions of enolase are present in both the cytoplasm and on the cell surface.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002808591-432Enolase

Structure

Family & Domains

Sequence similarities

Belongs to the enolase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    432
  • Mass (Da)
    47,045
  • Last updated
    2006-11-14 v1
  • Checksum
    BE8F14EADA776964
MSHNSQIQKIQAREIIDSRGNPTVEVDVTLMDGSFGRAAVPSGASTGEYEAVELRDGDKQRYLGKGVLKAVEHVNVKIQEILKGQDALDQNRVDQLMLDADGTKNKGKLGANAILGTSLAVAKAAAFHSKLPLYRYIGGNFARELPVPMMNIINGGAHADNNVDFQEFMILPVGAKNFREGLRMGAEVFHSLKSVLKGKKLNTAVGDEGGFAPDLTSNVEAIEVILQAIEKAGYKPEKDVLLGLDAASSEFYDKSKKKYVLGAENNKEFSSAELVDYYANLVSKYPIITIEDGLDENDWEGWKLLSEKLGKKIQLVGDDLFVTNIEKLSKGITSGVGNSILIKVNQIGSLSETLASIEMAKKAKYTNVVSHRSGETEDVTISHIAVATNAGQIKTGSLSRTDRIAKYNELLRIEEELGKSAVYKGKETFYNL

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000350
EMBL· GenBank· DDBJ
ABJ76131.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp