Q04NB3 · Q04NB3_LEPBJ

Function

function

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.

Catalytic activity

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1.

Features

Showing features for binding site, active site.

128020406080100120140160180200220240260280
Type
IDPosition(s)Description
Binding site33S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site64spermidine (UniProtKB | ChEBI)
Binding site88spermidine (UniProtKB | ChEBI)
Binding site108S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Binding site139-140S-methyl-5'-thioadenosine (UniProtKB | ChEBI)
Active site157Proton acceptor
Binding site157-160spermidine (UniProtKB | ChEBI)
Binding site164S-methyl-5'-thioadenosine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionspermidine synthase activity
Biological Processspermidine biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyamine aminopropyltransferase
  • Alternative names
    • Putrescine aminopropyltransferase
      (PAPT
      )
    • Spermidine synthase
      (SPDS
      ; SPDSY
      ) (EC:2.5.1.16
      ) . EC:2.5.1.16 (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      speE
    • Ordered locus names
      LBJ_4228

Organism names

Accessions

  • Primary accession
    Q04NB3

Proteomes

Subcellular Location

Interaction

Subunit

Homodimer or homotetramer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain2-237PABS

Sequence similarities

Belongs to the spermidine/spermine synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    280
  • Mass (Da)
    32,042
  • Last updated
    2006-11-14 v1
  • MD5 Checksum
    C7E8CD726892332517FAD19AC7B4C774
MELWLDEALELKNGRALKIKVKEFLHSRTTPFQKIDVFESVGFGRMFTLDGVVMMTEADEFAYHEMIVHVPMMSHPNPEKVLVIGGGDGGTVREVLKHPSVKEVHLCEIDKGVIDVCYEYFPEIANAMKDPRVKHAYEDGAKYVKDYRNYFDCIMVDSSDPVGPAEVLFKRPFYETMADCLKEGGICTTQGESYYYHGPIIRELFNFIPEIFKHCGYYYTVVPTYPSGIIGFTYCSKGPDPYTVIPDLQRVPQGLKYYSAEMHKAAFVLPQFAQKHIVRK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000351
EMBL· GenBank· DDBJ
ABJ77607.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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