Q04900 · MUC24_HUMAN

  • Protein
    Sialomucin core protein 24
  • Gene
    CD164
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendosome
Cellular Componentendosome membrane
Cellular Componentextracellular region
Cellular Componentlysosomal membrane
Cellular Componentlysosome
Cellular Componentplasma membrane
Biological Processcell adhesion
Biological Processhemopoiesis
Biological Processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processimmune response
Biological Processmuscle organ development
Biological Processnegative regulation of cell adhesion
Biological Processsignal transduction

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sialomucin core protein 24
  • Short names
    MUC-24
  • Alternative names
    • Endolyn
    • Multi-glycosylated core protein 24 (MGC-24; MGC-24v)
  • CD Antigen Name
    • CD164

Gene names

    • Name
      CD164

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q04900
  • Secondary accessions
    • B4DQ85
    • E1P5E7
    • E1P5E8
    • E1P5E9
    • O95413

Proteomes

Organism-specific databases

Subcellular Location

Lysosome membrane
; Single-pass type I membrane protein
Endosome membrane
; Single-pass type I membrane protein
Cell membrane
; Single-pass type I membrane protein

Isoform 2

Secreted

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain24-162Extracellular
Transmembrane163-183Helical
Topological domain184-197Cytoplasmic

Keywords

Disease & Variants

Involvement in disease

Deafness, autosomal dominant, 66 (DFNA66)

  • Note
    • The disease is caused by variants affecting the gene represented in this entry
  • Description
    A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
  • See also
    MIM:616969

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 237 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-23
ChainPRO_000001929224-197Sialomucin core protein 24
Glycosylation26N-linked (GlcNAc...) asparagine
Glycosylation32N-linked (GlcNAc...) asparagine
Glycosylation41N-linked (GlcNAc...) asparagine
Glycosylation72N-linked (GlcNAc...) asparagine
Glycosylation77N-linked (GlcNAc...) asparagine
Glycosylation94N-linked (GlcNAc...) asparagine
Glycosylation104N-linked (GlcNAc...) asparagine
Glycosylation121N-linked (GlcNAc...) asparagine
Glycosylation142O-linked (Xyl...) (glycosaminoglycan) serine
Glycosylation146N-linked (GlcNAc...) asparagine

Post-translational modification

Highly N- and O-glycosylated; contains sialic acid.
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.

Induction

Up-regulated by CXCL12 in prostate cancer cell lines.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Homodimer (isoform 4).
Interacts with CXCR4

Binary interactions

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region118-154Disordered
Region191-197Required for endosomal and lysosomal localization

Sequence similarities

Belongs to the CD164 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (5)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 5 isoforms produced by Alternative splicing.

Q04900-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    CD164(E1-6)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    197
  • Mass (Da)
    20,917
  • Last updated
    2009-09-01 v2
  • Checksum
    4855E02646F4CB35
MSRLSRSLLWAATCLGVLCVLSADKNTTQHPNVTTLAPISNVTSAPVTSLPLVTTPAPETCEGRNSCVSCFNVSVVNTTCFWIECKDESYCSHNSTVSDCQVGNTTDFCSVSTATPVPTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQPVRKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL

Q04900-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 175-197: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK

Q04900-3

  • Name
    3
  • Synonyms
    CD164(Delta 4)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q04900-4

  • Name
    4
  • Synonyms
    CD164(Delta 5)
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q04900-5

  • Name
    5
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
D6R9B4D6R9B4_HUMANCD164163

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_037972111-123in isoform 3
Alternative sequenceVSP_037973124-142in isoform 4
Alternative sequenceVSP_038018143-157in isoform 5
Alternative sequenceVSP_038019158-197in isoform 5
Alternative sequenceVSP_037974175-197in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D14043
EMBL· GenBank· DDBJ
BAA03130.1
EMBL· GenBank· DDBJ
mRNA
AF106518
EMBL· GenBank· DDBJ
AAC82473.1
EMBL· GenBank· DDBJ
mRNA
AF263279
EMBL· GenBank· DDBJ
AAF85965.1
EMBL· GenBank· DDBJ
mRNA
AF299341
EMBL· GenBank· DDBJ
AAG53906.1
EMBL· GenBank· DDBJ
mRNA
AF299342
EMBL· GenBank· DDBJ
AAG53907.1
EMBL· GenBank· DDBJ
mRNA
AF299343
EMBL· GenBank· DDBJ
AAG53908.1
EMBL· GenBank· DDBJ
mRNA
AF299340
EMBL· GenBank· DDBJ
AAG53903.1
EMBL· GenBank· DDBJ
Genomic DNA
AF299340
EMBL· GenBank· DDBJ
AAG53904.1
EMBL· GenBank· DDBJ
Genomic DNA
AF299340
EMBL· GenBank· DDBJ
AAG53905.1
EMBL· GenBank· DDBJ
Genomic DNA
AK298684
EMBL· GenBank· DDBJ
BAG60847.1
EMBL· GenBank· DDBJ
mRNA
AK303525
EMBL· GenBank· DDBJ
BAG64553.1
EMBL· GenBank· DDBJ
mRNA
AK312357
EMBL· GenBank· DDBJ
BAG35275.1
EMBL· GenBank· DDBJ
mRNA
AK315908
EMBL· GenBank· DDBJ
BAH14279.1
EMBL· GenBank· DDBJ
mRNA
AL359711
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471051
EMBL· GenBank· DDBJ
EAW48348.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471051
EMBL· GenBank· DDBJ
EAW48352.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471051
EMBL· GenBank· DDBJ
EAW48349.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471051
EMBL· GenBank· DDBJ
EAW48353.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471051
EMBL· GenBank· DDBJ
EAW48354.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471051
EMBL· GenBank· DDBJ
EAW48355.1
EMBL· GenBank· DDBJ
Genomic DNA
BC011522
EMBL· GenBank· DDBJ
AAH11522.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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