Q04900 · MUC24_HUMAN
- ProteinSialomucin core protein 24
- GeneCD164
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids197 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Sialomucin that may play a key role in hematopoiesis by facilitating the adhesion of CD34+ cells to the stroma and by negatively regulating CD34+CD38(lo/-) cell proliferation. Modulates the migration of umbilical cord blood CD133+ cells and this is mediated through the CXCL12/CXCR4 axis. May play an important role in prostate cancer metastasis and the infiltration of bone marrow by cancer cells. Promotes myogenesis by enhancing CXCR4-dependent cell motility. Positively regulates myoblast migration and promotes myoblast fusion into myotubes (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | endosome | |
Cellular Component | endosome membrane | |
Cellular Component | extracellular region | |
Cellular Component | lysosomal membrane | |
Cellular Component | lysosome | |
Cellular Component | plasma membrane | |
Biological Process | cell adhesion | |
Biological Process | hemopoiesis | |
Biological Process | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules | |
Biological Process | immune response | |
Biological Process | muscle organ development | |
Biological Process | negative regulation of cell adhesion | |
Biological Process | signal transduction |
Keywords
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameSialomucin core protein 24
- Short namesMUC-24
- Alternative names
- CD Antigen Name
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ04900
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Lysosome membrane ; Single-pass type I membrane protein
Endosome membrane ; Single-pass type I membrane protein
Cell membrane ; Single-pass type I membrane protein
Isoform 2
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 24-162 | Extracellular | ||||
Sequence: DKNTTQHPNVTTLAPISNVTSAPVTSLPLVTTPAPETCEGRNSCVSCFNVSVVNTTCFWIECKDESYCSHNSTVSDCQVGNTTDFCSVSTATPVPTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQPVRKSTFD | ||||||
Transmembrane | 163-183 | Helical | ||||
Sequence: AASFIGGIVLVLGVQAVIFFL | ||||||
Topological domain | 184-197 | Cytoplasmic | ||||
Sequence: YKFCKSKERNYHTL |
Keywords
- Cellular component
Disease & Variants
Involvement in disease
Deafness, autosomal dominant, 66 (DFNA66)
- Note
- DescriptionA form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
- See alsoMIM:616969
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 237 variants from UniProt as well as other sources including ClinVar and dbSNP.
Keywords
- Disease
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-23 | |||||
Sequence: MSRLSRSLLWAATCLGVLCVLSA | ||||||
Chain | PRO_0000019292 | 24-197 | Sialomucin core protein 24 | |||
Sequence: DKNTTQHPNVTTLAPISNVTSAPVTSLPLVTTPAPETCEGRNSCVSCFNVSVVNTTCFWIECKDESYCSHNSTVSDCQVGNTTDFCSVSTATPVPTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQPVRKSTFDAASFIGGIVLVLGVQAVIFFLYKFCKSKERNYHTL | ||||||
Glycosylation | 26 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 32 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 41 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 72 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 77 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 94 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 104 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 121 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 142 | O-linked (Xyl...) (glycosaminoglycan) serine | ||||
Sequence: S | ||||||
Glycosylation | 146 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Post-translational modification
Highly N- and O-glycosylated; contains sialic acid.
The motif Ser-Gly may serve as the site of attachment of a glycosaminoglycan side chain.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Isoform 1 and isoform 3 are expressed in hematopoietic and non-hematopoietic tissues. Isoform 1 is expressed by prostate cancer tumors and prostate cancer cell lines. The expression is greater in bone metastases than in primary tumors. Expression in osseous metastasis is greater than that in soft tissue metastasis. Isoform 2 is expressed in the small intestine, colon, lung, thyroid and in colorectal and pancreatic adenocarcinoma. Isoform 4 is expressed by both hematopoietic progenitor cells and bone marrow stromal cells.
Induction
Up-regulated by CXCL12 in prostate cancer cell lines.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Homodimer (isoform 4).
Interacts with CXCR4
Interacts with CXCR4
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q04900 | CXCR4 P61073 | 2 | EBI-2115896, EBI-489411 | |
BINARY | Q04900 | HOXA1 P49639 | 3 | EBI-2115896, EBI-740785 | |
BINARY | Q04900 | NOTCH2NLA Q7Z3S9 | 3 | EBI-2115896, EBI-945833 | |
BINARY | Q04900 | NOTCH2NLC P0DPK4 | 3 | EBI-2115896, EBI-22310682 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 118-154 | Disordered | ||||
Sequence: PTANSTAKPTVQPSPSTTSKTVTTSGTTNNTVTPTSQ | ||||||
Region | 191-197 | Required for endosomal and lysosomal localization | ||||
Sequence: ERNYHTL |
Sequence similarities
Belongs to the CD164 family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 5 isoforms produced by Alternative splicing.
Q04900-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsCD164(E1-6)
- Length197
- Mass (Da)20,917
- Last updated2009-09-01 v2
- Checksum4855E02646F4CB35
Q04900-2
- Name2
- Differences from canonical
- 175-197: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK
Q04900-3
- Name3
- SynonymsCD164(Delta 4)
- Differences from canonical
- 111-123: Missing
Q04900-4
- Name4
- SynonymsCD164(Delta 5)
- Differences from canonical
- 124-142: Missing
Q04900-5
- Name5
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
D6R9B4 | D6R9B4_HUMAN | CD164 | 163 |
Features
Showing features for alternative sequence.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_037972 | 111-123 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_037973 | 124-142 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_038018 | 143-157 | in isoform 5 | |||
Sequence: GTTNNTVTPTSQPVR → EIRCHTRNYIPDLKK | ||||||
Alternative sequence | VSP_038019 | 158-197 | in isoform 5 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_037974 | 175-197 | in isoform 2 | |||
Sequence: GVQAVIFFLYKFCKSKERNYHTL → EIRCHTRNYIPDLKK |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D14043 EMBL· GenBank· DDBJ | BAA03130.1 EMBL· GenBank· DDBJ | mRNA | ||
AF106518 EMBL· GenBank· DDBJ | AAC82473.1 EMBL· GenBank· DDBJ | mRNA | ||
AF263279 EMBL· GenBank· DDBJ | AAF85965.1 EMBL· GenBank· DDBJ | mRNA | ||
AF299341 EMBL· GenBank· DDBJ | AAG53906.1 EMBL· GenBank· DDBJ | mRNA | ||
AF299342 EMBL· GenBank· DDBJ | AAG53907.1 EMBL· GenBank· DDBJ | mRNA | ||
AF299343 EMBL· GenBank· DDBJ | AAG53908.1 EMBL· GenBank· DDBJ | mRNA | ||
AF299340 EMBL· GenBank· DDBJ | AAG53903.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF299340 EMBL· GenBank· DDBJ | AAG53904.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF299340 EMBL· GenBank· DDBJ | AAG53905.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AK298684 EMBL· GenBank· DDBJ | BAG60847.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303525 EMBL· GenBank· DDBJ | BAG64553.1 EMBL· GenBank· DDBJ | mRNA | ||
AK312357 EMBL· GenBank· DDBJ | BAG35275.1 EMBL· GenBank· DDBJ | mRNA | ||
AK315908 EMBL· GenBank· DDBJ | BAH14279.1 EMBL· GenBank· DDBJ | mRNA | ||
AL359711 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
CH471051 EMBL· GenBank· DDBJ | EAW48348.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471051 EMBL· GenBank· DDBJ | EAW48352.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471051 EMBL· GenBank· DDBJ | EAW48349.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471051 EMBL· GenBank· DDBJ | EAW48353.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471051 EMBL· GenBank· DDBJ | EAW48354.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471051 EMBL· GenBank· DDBJ | EAW48355.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC011522 EMBL· GenBank· DDBJ | AAH11522.1 EMBL· GenBank· DDBJ | mRNA |