Q04857 · CO6A1_MOUSE

  • Protein
    Collagen alpha-1(VI) chain
  • Gene
    Col6a1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Collagen VI acts as a cell-binding protein.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasement membrane
Cellular Componentcollagen trimer
Cellular Componentcollagen-containing extracellular matrix
Cellular Componentextracellular matrix
Cellular Componentextracellular region
Cellular Componentextracellular space
Cellular Componentintracellular vesicle
Cellular Componentlysosome
Cellular Componentmitochondrion
Cellular Componentmyofibril
Cellular Componentprotein-containing complex
Cellular Componentsarcolemma
Cellular Componentsarcoplasmic reticulum
Molecular Functioncollagen binding
Molecular Functionplatelet-derived growth factor binding
Biological Process2-oxoglutarate metabolic process
Biological Processadipose tissue development
Biological Processapoptotic nuclear changes
Biological Processapoptotic process
Biological Processautophagy
Biological Processbasement membrane organization
Biological Processbone development
Biological Processbone mineralization
Biological Processcanonical Wnt signaling pathway
Biological Processcartilage development
Biological Processcaveola assembly
Biological Processcell adhesion
Biological Processcell morphogenesis
Biological Processcellular response to amino acid stimulus
Biological Processcircadian rhythm
Biological Processcollagen fibril organization
Biological Processcollagen metabolic process
Biological Processendodermal cell differentiation
Biological Processenergy homeostasis
Biological Processenergy reserve metabolic process
Biological Processextracellular matrix assembly
Biological Processfat cell proliferation
Biological Processgene expression
Biological Processglycolytic process
Biological Processhair follicle development
Biological Processheart development
Biological Processhomeostasis of number of cells
Biological Processinflammatory response
Biological Processinsulin receptor signaling pathway
Biological Processinsulin-like growth factor receptor signaling pathway
Biological Processlimb joint morphogenesis
Biological Processlung alveolus development
Biological Processlung development
Biological Processlung epithelial cell differentiation
Biological Processlung morphogenesis
Biological Processmitochondrial depolarization
Biological Processmitochondrial transmembrane transport
Biological Processmitochondrion organization
Biological Processmulticellular organismal locomotion
Biological Processmuscle cell apoptotic process
Biological Processmuscle cell development
Biological Processmuscle organ development
Biological Processmuscle structure development
Biological Processmuscle system process
Biological Processmyelination in peripheral nervous system
Biological Processnervous system process
Biological Processneuron apoptotic process
Biological Processorganelle organization
Biological Processossification
Biological Processperipheral nervous system development
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processprotein tetramerization
Biological Processreactive oxygen species metabolic process
Biological Processreduction of food intake in response to dietary excess
Biological Processregulation of cell size
Biological Processregulation of collagen fibril organization
Biological Processrespiratory system process
Biological Processresponse to activity
Biological Processresponse to bleomycin
Biological Processresponse to decreased oxygen levels
Biological Processresponse to lipid
Biological Processresponse to lipopolysaccharide
Biological Processresponse to mechanical stimulus
Biological Processresponse to muscle activity
Biological Processresponse to pain
Biological Processresponse to peptide
Biological Processresponse to polyamine macromolecule
Biological Processresponse to reactive oxygen species
Biological Processresponse to toxic substance
Biological Processresponse to UV
Biological Processresponse to wounding
Biological Processresponse to xenobiotic stimulus
Biological Processsensory perception of mechanical stimulus
Biological Processsingle fertilization
Biological Processskeletal muscle fiber development
Biological Processskeletal muscle fiber differentiation
Biological Processskeletal muscle organ development
Biological Processskeletal muscle tissue development
Biological Processskeletal muscle tissue growth
Biological Processskeletal muscle tissue regeneration
Biological Processskin development
Biological Processtissue remodeling
Biological Processtransmission of nerve impulse
Biological Processtricarboxylic acid cycle
Biological Processuterus development

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Collagen alpha-1(VI) chain

Gene names

    • Name
      Col6a1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q04857

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000000575920-1025Collagen alpha-1(VI) chain
Glycosylation211N-linked (GlcNAc...) asparagine
Glycosylation515N-linked (GlcNAc...) asparagine
Glycosylation536N-linked (GlcNAc...) asparagine
Glycosylation801N-linked (GlcNAc...) asparagine
Glycosylation893N-linked (GlcNAc...) asparagine

Post-translational modification

Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Trimers composed of three different chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI) or alpha-4(VI) or alpha-5(VI) or alpha-6(VI).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, domain, motif, compositional bias.

TypeIDPosition(s)Description
Region20-255N-terminal globular domain
Domain36-234VWFA 1
Region252-588Disordered
Region256-591Triple-helical region
Motif261-263Cell attachment site
Compositional bias302-330Basic and acidic residues
Motif441-443Cell attachment site
Motif477-479Cell attachment site
Region592-1025C-terminal globular domain
Domain614-802VWFA 2
Domain826-1018VWFA 3

Sequence similarities

Belongs to the type VI collagen family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    1,025
  • Mass (Da)
    108,489
  • Last updated
    1994-06-01 v1
  • Checksum
    2A05DFED8771BBF7
MRLAHALLPLLLQACWVATQDIQGSKAIAFQDCPVDLFFVLDTSESVALRLKPYGALVDKVKSFTKRFIDNLRDRYYRCDRNLVWNAGALHYSDEVEIIRGLTRMPSGRDELKASVDAVKYFGKGTYTDCAIKKGLEELLIGGSHLKENKYLIVVTDGHPLEGYKEPCGGLEDAVNEAKHLGIKVFSVAITPDHLEPRLSIIATDHTYRRNFTAADWGHSRDAEEVISQTIDTIVDMIKNNVEQVCCSFECQAARGPPGPRGDPGYEGERGKPGLPGEKGEAGDPGRPGDLGPVGYQGMKGEKGSRGEKGSRGPKGYKGEKGKRGIDGVDGMKGETGYPGLPGCKGSPGFDGIQGPPGPKGDAGAFGMKGEKGEAGADGEAGRPGNSGSPGDEGDPGEPGPPGEKGEAGDEGNAGPDGAPGERGGPGERGPRGTPGVRGPRGDPGEAGPQGDQGREGPVGIPGDSGEAGPIGPKGYRGDEGPPGPEGLRGAPGPVGPPGDPGLMGERGEDGPPGNGTEGFPGFPGYPGNRGPPGLNGTKGYPGLKGDEGEVGDPGEDNNDISPRGVKGAKGYRGPEGPQGPPGHVGPPGPDECEILDIIMKMCSCCECTCGPIDILFVLDSSESIGLQNFEIAKDFIIKVIDRLSKDELVKFEPGQSHAGVVQYSHNQMQEHVDMRSPNVRNAQDFKEAVKKLQWMAGGTFTGEALQYTRDRLLPPTQNNRIALVITDGRSDTQRDTTPLSVLCGADIQVVSVGIKDVFGFVAGSDQLNVISCQGLSQGRPGISLVKENYAELLDDGFLKNITAQICIDKKCPDYTCPITFSSPADITILLDSSASVGSHNFETTKVFAKRLAERFLSAGRADPSQDVRVAVVQYSGQGQQQPGRAALQFLQNYTVLASSVDSMDFINDATDVNDALSYVTRFYREASSGATKKRVLLFSDGNSQGATAEAIEKAVQEAQRAGIEIFVVVVGPQVNEPHIRVLVTGKTAEYDVAFGERHLFRVPNYQALLRGVLYQTVSRKVALG

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias302-330Basic and acidic residues
Sequence conflict674-675in Ref. 2; CAA79152
Sequence conflict709in Ref. 2; CAA79152
Sequence conflict943in Ref. 2; CAA79152
Sequence conflict960in Ref. 2; CAA79152

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X66405
EMBL· GenBank· DDBJ
CAA47032.1
EMBL· GenBank· DDBJ
mRNA
X66406
EMBL· GenBank· DDBJ
CAA47033.1
EMBL· GenBank· DDBJ
Genomic DNA
Z18271
EMBL· GenBank· DDBJ
CAA79152.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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