Q046D1 · RPOC_LACGA

Function

function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 1 Mg2+ ion per subunit.
Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 2 Zn2+ ions per subunit.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site60Zn2+ 1 (UniProtKB | ChEBI)
Binding site62Zn2+ 1 (UniProtKB | ChEBI)
Binding site75Zn2+ 1 (UniProtKB | ChEBI)
Binding site78Zn2+ 1 (UniProtKB | ChEBI)
Binding site449Mg2+ (UniProtKB | ChEBI)
Binding site451Mg2+ (UniProtKB | ChEBI)
Binding site453Mg2+ (UniProtKB | ChEBI)
Binding site818Zn2+ 2 (UniProtKB | ChEBI)
Binding site892Zn2+ 2 (UniProtKB | ChEBI)
Binding site899Zn2+ 2 (UniProtKB | ChEBI)
Binding site902Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular ComponentDNA-directed RNA polymerase complex
Molecular FunctionDNA binding
Molecular FunctionDNA-directed 5'-3' RNA polymerase activity
Molecular Functionmagnesium ion binding
Molecular Functionzinc ion binding
Biological ProcessDNA-templated transcription

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    DNA-directed RNA polymerase subunit beta'
  • EC number
  • Short names
    RNAP subunit beta'
  • Alternative names
    • RNA polymerase subunit beta'
    • Transcriptase subunit beta'

Gene names

    • Name
      rpoC
    • Ordered locus names
      LGAS_0285

Organism names

Accessions

  • Primary accession
    Q046D1

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003088431-1223DNA-directed RNA polymerase subunit beta'

Interaction

Subunit

The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

Structure

Family & Domains

Sequence similarities

Belongs to the RNA polymerase beta' chain family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,223
  • Mass (Da)
    136,371
  • Last updated
    2006-11-14 v1
  • Checksum
    8956074C0A19132C
MIDVNKFESMQIGLASPNKIRSWSYGEVKKPETINYRTLKPEKDGLFDERIFGPTKDWSCACGKYKGIRYRGIVCDRCGVEVTSAKVRRERMGHIELAAPVSHIWYFKGIPSRMGLVLDISPRALEEVIYFAAYIVIDAGDTDLEDKQLLTEAEYREKKAKFGNRFEAKMGAEAVKELLEQVDIDKEVHDLKEELKTATGQKRTRAIRRLDILDAFKNSGNKPSWMVMDCIPVIPPDLRPMVQLDGGRFATSDLNDLYRRVINRNNRLKRLLDLNAPRIIVQNEKRMLQEAVDALIDNGRRGRPVVGPGNRPLKSLSHMLKGKQGRFRQNLLGKRVDYSGRSVIDVSPKLKFYQCGVPRPMALELFKPFVMHELVKRGLASNIKNAKRKIDREDDDIWDILEDVIKERPVLLNRAPTLHRLGIQAFEPVLVPGKSIRLHPLACEAYNADFDGDQMAIHVPLSDEAVAESRLLMLAAHHILAPKDGKPIVTPSQDIVLGNYWLTQAERGREGEGMIFDSPAEAAIAYANGDIHYHTRIGLAADSMPEKPWPKGYEHGIFVTTYGKLVFNQIFPKDFFYINDPTQENLTHPVDERYFLQPGEDIHEKLDNMKLGKAFKKGFLSDSIAQIYKDYKVQRTSDFLDDLKELGYTVCTTSGLTIGVEDIPTITDKDDIVAEARKKVDVVSKQYRRGLITDEERHDRVISIWNNCKDIVQNEIAQIHAPRNPITIMADSGARGNISNFTQLAGMRGLMAAPNGGMMEIPVTSNFREGLSVLEMFMSTHGARKGMTDTALKTANSGYLTRRLVDVAQDVIIREEDCGTDRGLTVHAITEGDEMIEPLFDRLVGRYTSKSVYDPETHEVICPADVLMDEDMAHKIVDAGVTEVTIRSVFTCNTQHGVCKKCYGMNLATGDDVEVGEAVGTVAAQSIGEPGTQLTMRNFHNGGVAGAADITQGLPRVQELFEARNPKGRATISEVTGEITSIEEDPAEHTRQITVKGQTDTRTYDVPYTASVAVAEGDHVVRGDKLTLGSIDPKELIRVRDALTTEKYILSEIQKAYRMQGVEIADKHVEVMARQMLQKVRILDPGETDILPGELMDIGEFKARNREVIISGGIPATAQSVILGITKAALETNSFLSAASFQETTRVLTDASIRGKNDPLLGLKENVIIGKIIPAGTGMPVYREMEPKVDVPEDEKKKSVYSIADIEKKLAAADAEKDKGSAD

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000413
EMBL· GenBank· DDBJ
ABJ59691.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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