Q04664 · CPSE_STRA3
- ProteinGalactosyl transferase CpsE
- GenecpsE
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids449 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Galactosyl transferase is essential for the assembly of the group B streptococci (GBS) type III capsular polysaccharide. May be involved in the formation of either or both galactosidic bonds by catalyzing the addition of galactose to an oligosaccharide precursor or to a lipid intermediate. Type III capsular polysaccharide consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought to be an important element in the virulence function of the capsule.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | phosphotransferase activity, for other substituted phosphate groups | |
Biological Process | polysaccharide biosynthetic process |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGalactosyl transferase CpsE
- EC number
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Streptococcaceae > Streptococcus
Accessions
- Primary accessionQ04664
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 5-22 | Helical | |||
Transmembrane | 27-46 | Helical | |||
Transmembrane | 59-78 | Helical | |||
Transmembrane | 88-107 | Helical | |||
Transmembrane | 258-280 | Helical | |||
Keywords
- Cellular component
Phenotypes & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 262 | in strain: SG96/585 / Serotype III | |||
Natural variant | 370 | in strain: COH1 / Serotype III | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000166463 | 1-449 | Galactosyl transferase CpsE | ||
Structure
Sequence
- Sequence statusComplete
- Length449
- Mass (Da)52,378
- Last updated2003-01-17 v3
- ChecksumA958FE1E0DA01338
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF163833 EMBL· GenBank· DDBJ | AAD53066.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF332896 EMBL· GenBank· DDBJ | AAL57072.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF332897 EMBL· GenBank· DDBJ | AAL57079.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF332898 EMBL· GenBank· DDBJ | AAL57085.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF332899 EMBL· GenBank· DDBJ | AAL57091.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF332900 EMBL· GenBank· DDBJ | AAL57097.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363032 EMBL· GenBank· DDBJ | AAL56269.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363033 EMBL· GenBank· DDBJ | AAL56273.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363034 EMBL· GenBank· DDBJ | AAL56277.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363035 EMBL· GenBank· DDBJ | AAL56281.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363039 EMBL· GenBank· DDBJ | AAL56297.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363040 EMBL· GenBank· DDBJ | AAL56301.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363055 EMBL· GenBank· DDBJ | AAL56361.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF363056 EMBL· GenBank· DDBJ | AAL56368.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF381031 EMBL· GenBank· DDBJ | AAL57286.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF367973 EMBL· GenBank· DDBJ | AAL56403.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL766849 EMBL· GenBank· DDBJ | CAD46903.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |