Q04664 · CPSE_STRA3

Function

function

Galactosyl transferase is essential for the assembly of the group B streptococci (GBS) type III capsular polysaccharide. May be involved in the formation of either or both galactosidic bonds by catalyzing the addition of galactose to an oligosaccharide precursor or to a lipid intermediate. Type III capsular polysaccharide consists of a linear backbone with short side chains ending in residues of N-acetylneuraminic acid or sialic acid. The presence of sialic acid on the surface of the organism inhibits activation of the alternative pathway of complement and is thought to be an important element in the virulence function of the capsule.

Caution

Was originally called CpsD.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentplasma membrane
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processpolysaccharide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

Gene names

    • Name
      cpsE
    • Ordered locus names
      gbs1244

Organism names

Accessions

  • Primary accession
    Q04664
  • Secondary accessions
    • Q8VL98
    • Q8VSS5
    • Q9JN35

Proteomes

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane5-22Helical
Transmembrane27-46Helical
Transmembrane59-78Helical
Transmembrane88-107Helical
Transmembrane258-280Helical

Keywords

Phenotypes & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant262in strain: SG96/585 / Serotype III
Natural variant370in strain: COH1 / Serotype III

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001664631-449Galactosyl transferase CpsE

Structure

Family & Domains

Sequence similarities

Belongs to the bacterial sugar transferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    449
  • Mass (Da)
    52,378
  • Last updated
    2003-01-17 v3
  • Checksum
    A958FE1E0DA01338
MIQTVVVYFSASLTLTLITPNFKSNKDLLFVLLIHYIVFYLSDFYRDFWSRGYLEEFKMVLKYSFYYIFISSSLFFIFKNSFTTTRLSFFTFIAMNSILLYLLNSFLKYYRKYSYAKFSRDTKVVLITNKDSLSKMTFRNKYDHNYIAVCILDSSEKDCYDLKHNSLRIINKDALTSELTCLTVDQAFINIPIELFGKYQIQDIINDIEAMGVIVNVNVEALSFDNIGEKRIQTFEGYSVITYSMKFYKYSHLIAKRFLDITGAIIGLLICGIVAIFLVPQIRKDGGPAIFSQNRVGRNGRIFRFYKFRSMRVDAEQIKKDLLVHNQMTGLMFKLEDDPRITKIGKFIRKTSIDELPQFYNVLKGDMSLVGTRPPTVDEYEKYNSTQKRRLSFKPGITGLWQISGRNNITDFDEIVKLDVQYINEWSIWSDIKIILLTLKVVLLGTGAK

Sequence caution

The sequence CAD46903.1 differs from that shown. Reason: Erroneous initiation

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF163833
EMBL· GenBank· DDBJ
AAD53066.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332896
EMBL· GenBank· DDBJ
AAL57072.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332897
EMBL· GenBank· DDBJ
AAL57079.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332898
EMBL· GenBank· DDBJ
AAL57085.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332899
EMBL· GenBank· DDBJ
AAL57091.1
EMBL· GenBank· DDBJ
Genomic DNA
AF332900
EMBL· GenBank· DDBJ
AAL57097.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363032
EMBL· GenBank· DDBJ
AAL56269.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363033
EMBL· GenBank· DDBJ
AAL56273.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363034
EMBL· GenBank· DDBJ
AAL56277.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363035
EMBL· GenBank· DDBJ
AAL56281.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363039
EMBL· GenBank· DDBJ
AAL56297.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363040
EMBL· GenBank· DDBJ
AAL56301.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363055
EMBL· GenBank· DDBJ
AAL56361.1
EMBL· GenBank· DDBJ
Genomic DNA
AF363056
EMBL· GenBank· DDBJ
AAL56368.1
EMBL· GenBank· DDBJ
Genomic DNA
AF381031
EMBL· GenBank· DDBJ
AAL57286.1
EMBL· GenBank· DDBJ
Genomic DNA
AF367973
EMBL· GenBank· DDBJ
AAL56403.1
EMBL· GenBank· DDBJ
Genomic DNA
AL766849
EMBL· GenBank· DDBJ
CAD46903.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

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