Q04641 · SCTC_SHIFL

  • Protein
    Type 3 secretion system secretin
  • Gene
    sctC
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:8437520).
Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (PubMed:11717255).
Necessary for the secretion of Ipa invasins (PubMed:8437520).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell outer membrane
Cellular Componenttype II protein secretion system complex
Cellular Componenttype III protein secretion system complex
Biological Processprotein secretion by the type III secretion system

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Type 3 secretion system secretin
  • Short names
    T3SS secretin
  • Alternative names
    • Outer membrane protein MxiD

Gene names

    • Name
      sctC
    • Synonyms
      mxiD
    • Ordered locus names
      CP0145

Encoded on

  • Plasmid pWR100
  • Plasmid pWR501
  • Plasmid pCP301

Organism names

  • Taxonomic identifier
  • Strains
    • M90T / Serotype 5a
    • 301 / Serotype 2a
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella

Accessions

  • Primary accession
    Q04641
  • Secondary accessions
    • Q8VSH0

Proteomes

Subcellular Location

Cell outer membrane
Note: Localization to the outer membrane requires MxiM/SctG.

Keywords

Phenotypes & Variants

Disruption phenotype

Inactivated mutant strain is unable to invade HeLa cells and to provoke keratoconjunctivitis in guinea-pigs.

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variant296in plasmid pCP301

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-22
ChainPRO_000001311223-566Type 3 secretion system secretin

Proteomic databases

Interaction

Subunit

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569).
This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope (PubMed:11717255).
Forms a stable homooligomeric complex (PubMed:11717255).
Interacts with the pilotin MxiM/SctG and the inner membrane ring outer protein MxiJ/SctJ (PubMed:11717255, PubMed:18940609).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q04641mxiM P0A1X23EBI-15735324, EBI-15735345

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the bacterial secretin family. T3SS SctC subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    566
  • Mass (Da)
    63,173
  • Last updated
    1994-06-01 v1
  • Checksum
    56B0D80BB16C2431
MKKFNIKSLTLLIVLLPLIVNANNIDSHLLEQNDIAKYVAQSDTVGSFFERFSALLNYPIVVSKQAAKKRISGEFDLSNPEEMLEKLTLLVGLIWYKDGNALYIYDSGELISKVILLENISLNYLIQYLKDANLYDHRYPIRGNISDKTFYISGPPALVELVANTATLLDKQVSSIGTDKVNFGVIKLKNTFVSDRTYNMRGEDIVIPGVATVVERLLNNGKALSNRQAQNDPMPPFNITQKVSEDSNDFSFSSVTNSSILEDVSLIAYPETNSILVKGNDQQIQIIRDIITQLDVAKRHIELSLWIIDIDKSELNNLGVNWQGTASFGDSFGASFNMSSSASISTLDGNKFIASVMALNQKKKANVVSRPVILTQENIPAIFDNNRTFYVSLVGERNSSLEHVTYGTLINVIPRFSSRGQIEMSLTIEDGTGNSQSNYNYNNENTSVLPEVGRTKISTIARVPQGKSLLIGGYTHETNSNEIISIPFLSSIPVIGNVFKYKTSNISNIVRVFLIQPREIKESSYYNTAEYKSLISEREIQKTTQIIPSETTLLEDEKSLVSYLNY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
X67206
EMBL· GenBank· DDBJ
CAA47644.1
EMBL· GenBank· DDBJ
Genomic DNA
AL391753
EMBL· GenBank· DDBJ
CAC05820.1
EMBL· GenBank· DDBJ
Genomic DNA
AF348706
EMBL· GenBank· DDBJ
AAK18464.1
EMBL· GenBank· DDBJ
Genomic DNA
AF386526
EMBL· GenBank· DDBJ
AAL72331.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Help