Q04641 · SCTC_SHIFL
- ProteinType 3 secretion system secretin
- GenesctC
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids566 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Component of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (PubMed:8437520).
Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (PubMed:11717255).
Necessary for the secretion of Ipa invasins (PubMed:8437520).
Forms a ring-shaped multimeric structure with an apparent central pore in the outer membrane (PubMed:11717255).
Necessary for the secretion of Ipa invasins (PubMed:8437520).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell outer membrane | |
Cellular Component | type II protein secretion system complex | |
Cellular Component | type III protein secretion system complex | |
Biological Process | protein secretion by the type III secretion system |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameType 3 secretion system secretin
- Short namesT3SS secretin
- Alternative names
Gene names
Encoded on
- Plasmid pWR100
- Plasmid pWR501
- Plasmid pCP301
Organism names
- Organism
- Strains
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Shigella
Accessions
- Primary accessionQ04641
- Secondary accessions
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Localization to the outer membrane requires MxiM/SctG.
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Inactivated mutant strain is unable to invade HeLa cells and to provoke keratoconjunctivitis in guinea-pigs.
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Natural variant | 296 | in plasmid pCP301 | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-22 | ||||
Chain | PRO_0000013112 | 23-566 | Type 3 secretion system secretin | ||
Proteomic databases
Interaction
Subunit
The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569).
This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope (PubMed:11717255).
Forms a stable homooligomeric complex (PubMed:11717255).
Interacts with the pilotin MxiM/SctG and the inner membrane ring outer protein MxiJ/SctJ (PubMed:11717255, PubMed:18940609).
This subunit is part of the base, which anchors the injectisome in the bacterial cell envelope (PubMed:11717255).
Forms a stable homooligomeric complex (PubMed:11717255).
Interacts with the pilotin MxiM/SctG and the inner membrane ring outer protein MxiJ/SctJ (PubMed:11717255, PubMed:18940609).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q04641 | mxiM P0A1X2 | 3 | EBI-15735324, EBI-15735345 |
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length566
- Mass (Da)63,173
- Last updated1994-06-01 v1
- Checksum56B0D80BB16C2431
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
X67206 EMBL· GenBank· DDBJ | CAA47644.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL391753 EMBL· GenBank· DDBJ | CAC05820.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF348706 EMBL· GenBank· DDBJ | AAK18464.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF386526 EMBL· GenBank· DDBJ | AAL72331.1 EMBL· GenBank· DDBJ | Genomic DNA |