Q045P1 · MUTS2_LACGA
- ProteinEndonuclease MutS2
- GenemutS2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids791 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity.
Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 337-344 | ATP (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | ATP binding | |
Molecular Function | ATP hydrolysis activity | |
Molecular Function | endonuclease activity | |
Molecular Function | mismatched DNA binding | |
Biological Process | mismatch repair | |
Biological Process | negative regulation of DNA recombination |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameEndonuclease MutS2
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus
Accessions
- Primary accessionQ045P1
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_1000093364 | 1-791 | Endonuclease MutS2 | ||
Interaction
Subunit
Homodimer. Binds to stalled ribosomes, contacting rRNA.
Structure
Family & Domains
Features
Showing features for compositional bias, region, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 689-705 | Basic and acidic residues | |||
Region | 689-715 | Disordered | |||
Domain | 716-791 | Smr | |||
Sequence similarities
Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length791
- Mass (Da)88,908
- Last updated2006-11-14 v1
- MD5 Checksum1F672BD357E1EFAE647825C43F8911CF
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 689-705 | Basic and acidic residues | |||
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000413 EMBL· GenBank· DDBJ | ABJ59831.1 EMBL· GenBank· DDBJ | Genomic DNA |