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Q045P1 · MUTS2_LACGA

Function

function

Endonuclease that is involved in the suppression of homologous recombination and thus may have a key role in the control of bacterial genetic diversity.
Acts as a ribosome collision sensor, splitting the ribosome into its 2 subunits. Detects stalled/collided 70S ribosomes which it binds and splits by an ATP-hydrolysis driven conformational change. Acts upstream of the ribosome quality control system (RQC), a ribosome-associated complex that mediates the extraction of incompletely synthesized nascent chains from stalled ribosomes and their subsequent degradation. Probably generates substrates for RQC.

Features

Showing features for binding site.

1791100200300400500600700
TypeIDPosition(s)Description
Binding site337-344ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular FunctionATP binding
Molecular FunctionATP hydrolysis activity
Molecular Functionendonuclease activity
Molecular Functionmismatched DNA binding
Biological Processmismatch repair
Biological Processnegative regulation of DNA recombination

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Endonuclease MutS2
  • EC number
  • Alternative names
    • Ribosome-associated protein quality control-upstream factor
      (RQC-upstream factor
      ; RqcU
      ) (EC:3.6.4.-
      ) . EC:3.6.4.- (UniProtKB | ENZYME | Rhea)

Gene names

    • Name
      mutS2
    • Synonyms
      rqcU
    • Ordered locus names
      LGAS_0426

Organism names

Accessions

  • Primary accession
    Q045P1

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000933641-791Endonuclease MutS2

Interaction

Subunit

Homodimer. Binds to stalled ribosomes, contacting rRNA.

Structure

Family & Domains

Features

Showing features for compositional bias, region, domain.

Type
IDPosition(s)Description
Compositional bias689-705Basic and acidic residues
Region689-715Disordered
Domain716-791Smr

Sequence similarities

Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    791
  • Mass (Da)
    88,908
  • Last updated
    2006-11-14 v1
  • MD5 Checksum
    1F672BD357E1EFAE647825C43F8911CF
MEDMNSKIIEKLEYNRIIRQLSDLAITAPAKAQALKLMPSSDFDEVKKSIDQTRVLSNILRVKGPMPITDFKDVRPSLKRLKVKANLNGEELGNIFLVLSLAKDVGQFASDLEEREIDTRPIEKYLKNLAVPEDLFKKLNQAIEYDGTVKDTASSKLMQLRHDIQSNETDIKNHMNDYISGKHTQYLSENIVTIRDGRYVLPVKQEYKNKFGGVVHDQSASGQTLFVEPQAVLVLNNRQQNLLAQERQEIHRILIELSELAGAYQKEINNNALALTQLDFLSAKSKLAKKMKATEPVLNQDHIIKLRKARHPLIDPKKVVPNNIELGTTFDTMLITGPNTGGKTITLKTLGLLQLMAQAGLFITAEEGSQLTVFNEIYADIGDEQSIEQSLSTFSSHMDQIIKIMNNVTEDDLVLIDELGAGTDPEEGASLAIAILDDLRQTQAKIAITTHYPELKLYGYNRKRTTNASMEFDLKKLAPTYRLRIGIPGQSNAFAIAHQLGMNEAVVDKARDLMNDEDSDINKMIERLTEQTKAAEQLHETLKQNVDQSITLKRQLQNGLDWYNQQVQKQLEKSQEKADEMLAKKRKQAEKIINDLEEQRRAGGQVRTNKVIEAKGALNKLERENQNLANNKVLQREKKRHDVSVGDNVKVLSYGQQGVITKKLGEHEFEVQIGILKVKVTDRDVEKIAAQASQKKPEKSVRSSRGLRSSRASSELDLRGQRYEEALTNLDRYLDASLLAGLNTVTIIHGIGTGAIRNGVQQYLKRNRHVKSYNYAPANQGGTGATIVNLQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias689-705Basic and acidic residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000413
EMBL· GenBank· DDBJ
ABJ59831.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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