Q041L3 · RTPR_LACGA
- ProteinAdenosylcobalamin-dependent ribonucleoside-triphosphate reductase
- GenertpR
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids744 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
Catalytic activity
- a 2'-deoxyribonucleoside 5'-triphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-triphosphate + [thioredoxin]-dithiol
CHEBI:61560 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = CHEBI:61557 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Activity regulation
Allosterically regulated by ATP and dNTP.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 413 | ||||
Active site | 415 | ||||
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | cobalamin binding | |
Molecular Function | nucleotide binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Molecular Function | ribonucleoside-triphosphate reductase (thioredoxin) activity | |
Biological Process | DNA replication |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameAdenosylcobalamin-dependent ribonucleoside-triphosphate reductase
- EC number
- Short namesRTPR
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Bacillota > Bacilli > Lactobacillales > Lactobacillaceae > Lactobacillus
Accessions
- Primary accessionQ041L3
Proteomes
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000326541 | 1-744 | Adenosylcobalamin-dependent ribonucleoside-triphosphate reductase | ||
Disulfide bond | 120↔424 | Redox-active | |||
Keywords
- PTM
Interaction
Subunit
Monomer.
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 148-159 | Effector region-1 | |||
Region | 169-318 | Effector region-2 | |||
Region | 570-631 | Adenosylcobalamin-binding-1 | |||
Region | 690-729 | Adenosylcobalamin-binding-2 | |||
Sequence similarities
Belongs to the class II ribonucleoside-triphosphate reductase family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length744
- Mass (Da)83,638
- Last updated2008-04-08 v2
- MD5 ChecksumC9688081E6146BE896F30972D79506BB
Sequence caution
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
CP000413 EMBL· GenBank· DDBJ | ABJ60859.1 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation |