Q03TT0 · GUAC_LEVBA

Function

function

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.

Catalytic activity

Features

Showing features for active site, binding site.

132850100150200250300
Type
IDPosition(s)Description
Active site177Thioimidate intermediate
Binding site206-229NADP+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Cellular ComponentGMP reductase complex
Molecular FunctionGMP reductase activity
Biological Processpurine nucleotide metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GMP reductase
  • EC number
  • Alternative names
    • Guanosine 5'-monophosphate oxidoreductase
      (Guanosine monophosphate reductase
      )

Gene names

    • Name
      guaC
    • Ordered locus names
      LVIS_0226

Organism names

Accessions

  • Primary accession
    Q03TT0

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002920501-328GMP reductase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    328
  • Mass (Da)
    36,006
  • Last updated
    2006-11-14 v1
  • Checksum
    DD7A0C66BF41F14B
MHPAEVFDYEDIQLVPNKCIIDSRSEADTSIEFGPRRFKIPVVPANMETVINEPLAVWLAEHDYFYVMHRFQPEDRRGFIERMQAKSLFASISVGVKPEEVTFIDELATAGLTPEYITIDIAHGHSDAVIRMIHHIKQQLPNSFVIAGNVGTPEAVRELENAGADATKVGIGPGKACITKLKTGFGTGGWQLAAVRLCAKAARKPIVADGGIRYNGDIAKSIRFGASMVMIGSMLAGHEQSPGSLLTIDGRTFKQYWGSASEKQKGAYRNVEGKQMLVPYRGDIDQTLTAMEEDLQSAISYAGGRNLLDIRTVDYVIVKSSILNGDNY

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000416
EMBL· GenBank· DDBJ
ABJ63392.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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