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Q038Q9 · DTD_LACP3

Function

function

An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.

Catalytic activity

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionD-tyrosyl-tRNA(Tyr) deacylase activity
Molecular FunctionGly-tRNA(Ala) hydrolase activity
Molecular FunctionSer(Gly)-tRNA(Ala) hydrolase activity
Molecular FunctiontRNA binding
Biological ProcessD-amino acid catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    D-aminoacyl-tRNA deacylase
  • EC number
  • Short names
    DTD
  • Alternative names
    • Gly-tRNA(Ala) deacylase

Gene names

    • Name
      dtd
    • Ordered locus names
      LSEI_1538

Organism names

Accessions

  • Primary accession
    Q038Q9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_10000508431-148D-aminoacyl-tRNA deacylase

Proteomic databases

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for motif.

TypeIDPosition(s)Description
Motif137-138Gly-cisPro motif, important for rejection of L-amino acids

Domain

A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.

Sequence similarities

Belongs to the DTD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    148
  • Mass (Da)
    15,629
  • Last updated
    2006-11-14 v1
  • MD5 Checksum
    A13BD39D12F36A78C951CDEE64CDB99F
MRAVVQRSLEAKVTIEGNTVGTIDHGFVVLLGVGPTDTEADSDYLAEKISKLRVFSDPVGKMNLALADVGGQVLSISQFTLYADTHRGNRPSFTGAADPALGDRLYQAFNAKLKALGVPVATGEFGGDMQVSLTNDGPVTILFDTEAK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000423
EMBL· GenBank· DDBJ
ABJ70313.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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