Q03898 · FIN1_YEAST
- ProteinFilament protein FIN1
- GeneFIN1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids291 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Forms cell-cycle specific filaments between the spindle pole bodies of dividing yeast cells.
Miscellaneous
Strong overexpression results in the accumulation of filamentous structures resembling the neurofibrillary tangles found in cells of patients with Alzheimer disease.
Overexpression is lethal in haploids and causes very poor growth in diploids.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | astral microtubule | |
Cellular Component | cytoplasm | |
Cellular Component | intermediate filament | |
Cellular Component | kinetochore | |
Cellular Component | mitotic spindle | |
Cellular Component | nucleus | |
Cellular Component | protein phosphatase type 1 complex | |
Cellular Component | spindle microtubule | |
Cellular Component | spindle pole | |
Cellular Component | spindle pole body | |
Molecular Function | microtubule binding | |
Molecular Function | structural constituent of cytoskeleton | |
Biological Process | deactivation of mitotic spindle assembly checkpoint | |
Biological Process | intermediate filament cytoskeleton organization | |
Biological Process | mitotic sister chromatid segregation | |
Biological Process | mitotic spindle organization | |
Biological Process | protein localization to kinetochore |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameFilament protein FIN1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Fungi > Dikarya > Ascomycota > Saccharomycotina > Saccharomycetes > Saccharomycetales > Saccharomycetaceae > Saccharomyces
Accessions
- Primary accessionQ03898
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: Nuclear during early bud formation, located at the spindle poles during late mitosis, very low abundance in resting cells.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000087257 | 1-291 | Filament protein FIN1 | |||
Sequence: MSNKSNRRSLRDIGNTIGRNNIPSDKDNVFVRLSMSPLRTTSQKEFLKPPMRISPNKTDGMKHSIQVTPRRIMSPECLKGYVSKETQSLDRPQFKNSNKNVKIQNSDHITNIIFPTSPTKLTFSNENKIGGDGSLTRIRARFKNGLMSPERIQQQQQQHILPSDAKSNTDLCSNTELKDAPFENDLPRAKLKGKNLLVELKKEEEDVGNGIESLTKSNTKLNSMLANEGKIHKASFQKSVKFKLPDNIVTEETVELKEIKDLLLQMLRRQREIESRLSNIELQLTEIPKHK | ||||||
Modified residue | 54 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 68 | Phosphothreonine | ||||
Sequence: T | ||||||
Modified residue | 74 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 88 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Phosphorylated by CDC28. Phosphorylation is required for BMH1 and BMH2 interaction. Dephosphorylation by GLC7 depends on the presence of BMH1 and BMH2.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Induction
Induced during G2-M transition.
Interaction
Subunit
Homooligomer; in vitro, FIN1 self-assembles into 10 nm diameter filaments. Interacts with the 14-3-3 proteins BMH1 and BMH2, and the protein phosphatase 1 complex catalytic subunit GLC7.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q03898 | CDC14 Q00684 | 2 | EBI-32941, EBI-4192 | |
BINARY | Q03898 | CLB2 P24869 | 2 | EBI-32941, EBI-4515 | |
BINARY | Q03898 | GLC7 P32598 | 3 | EBI-32941, EBI-13715 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Coiled coil | 254-284 | |||||
Sequence: VELKEIKDLLLQMLRRQREIESRLSNIELQL |
Domain
The coiled coil domain is essential for dimerization.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length291
- Mass (Da)33,186
- Last updated1996-11-01 v1
- ChecksumFD4DB73A50F50172
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
Z48179 EMBL· GenBank· DDBJ | CAA88211.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY557684 EMBL· GenBank· DDBJ | AAS56010.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BK006938 EMBL· GenBank· DDBJ | DAA11976.1 EMBL· GenBank· DDBJ | Genomic DNA |