Q03614 · NTDO_CAEEL
- ProteinSodium-dependent dopamine transporter
- Genedat-1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids615 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Dopamine transporter (PubMed:29346382, PubMed:9765501).
Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Plays a role in the learned avoidance behavior of animals exposed to food that induces mitochondrial stress (PubMed:35074444).
Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals. Plays a role in the learned avoidance behavior of animals exposed to food that induces mitochondrial stress (PubMed:35074444).
Miscellaneous
This protein is the target of psychomotor stimulants such as amphetamines or cocaine. Plays a role in promoting amphetamine-induced loss of motility in water, termed swimming-induced paralysis (PubMed:20410438).
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 55 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 57 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 58 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 62 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 314 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 346 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 411 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 414 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 415 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Keywords
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameSodium-dependent dopamine transporter
- Short namesDA transporter; DAT
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Nematoda > Chromadorea > Rhabditida > Rhabditina > Rhabditomorpha > Rhabditoidea > Rhabditidae > Peloderinae > Caenorhabditis
Accessions
- Primary accessionQ03614
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-46 | Cytoplasmic | ||||
Sequence: MQLVPTDDPDEKIGRTSNGMQNATLPIDGPVNTEPKDPAREQWSGK | ||||||
Transmembrane | 47-72 | Helical; Name=1 | ||||
Sequence: LDFLLSVVGFAVDLGNIWRFPYLCFK | ||||||
Topological domain | 73-76 | Extracellular | ||||
Sequence: NGGG | ||||||
Transmembrane | 77-100 | Helical; Name=2 | ||||
Sequence: VFLIPYSIMVLLTGVPLFYMELCL | ||||||
Topological domain | 101-120 | Cytoplasmic | ||||
Sequence: GQYYRKGAITTWGRICPLFK | ||||||
Transmembrane | 121-151 | Helical; Name=3 | ||||
Sequence: GIGYCVILTAFYVDFFYNVILAWGLHYLYTS | ||||||
Topological domain | 152-229 | Extracellular | ||||
Sequence: FSFNLPWASCNNSYNSPACYEPHWSEDGTAMCRSANQSVSAEKISAAEEYFYKGFLGLHEANAPNSHVIRSVTDLGNV | ||||||
Transmembrane | 230-250 | Helical; Name=4 | ||||
Sequence: RWDIALSLFVVYLICYFSMWK | ||||||
Topological domain | 251-253 | Cytoplasmic | ||||
Sequence: GIH | ||||||
Transmembrane | 254-278 | Helical; Name=5 | ||||
Sequence: TSGKVVWFTALFPYVVLGILFIRGV | ||||||
Topological domain | 279-302 | Extracellular | ||||
Sequence: TLPGWQNGIEYYLRPNFEMLKRPS | ||||||
Transmembrane | 303-328 | Helical; Name=6 | ||||
Sequence: VWQDAATQVFFSLGPGFGVLMAYSSY | ||||||
Topological domain | 329-334 | Cytoplasmic | ||||
Sequence: NDFHNN | ||||||
Transmembrane | 335-358 | Helical; Name=7 | ||||
Sequence: VYVDALFTSFINCATSFLSGFVIF | ||||||
Topological domain | 359-398 | Extracellular | ||||
Sequence: SVLGYMSCKSGKPIEAVAQEGPGLVFVVYPEALSTMPYAP | ||||||
Transmembrane | 399-424 | Helical; Name=8 | ||||
Sequence: FWSVLFFLMLMTLGLDSSFGGSEAII | ||||||
Topological domain | 425-439 | Cytoplasmic | ||||
Sequence: TGLSDEFPILKKNRE | ||||||
Transmembrane | 440-460 | Helical; Name=9 | ||||
Sequence: VFVGCLFAFYMVIGIAMCTEG | ||||||
Topological domain | 461 | Extracellular | ||||
Sequence: G | ||||||
Transmembrane | 462-488 | Helical; Name=10 | ||||
Sequence: ILIMEWLIIYGTTWGLLIAVFCEAMVI | ||||||
Topological domain | 489-518 | Cytoplasmic | ||||
Sequence: AYIYGLRQFVHDVKEMMGFRPGNYWKFCWS | ||||||
Transmembrane | 519-541 | Helical; Name=11 | ||||
Sequence: CAAPFILLSMITSNFINYQALTY | ||||||
Topological domain | 542-544 | Extracellular | ||||
Sequence: QDY | ||||||
Transmembrane | 545-565 | Helical; Name=12 | ||||
Sequence: TYPTAANVIGIIFALSGASFI | ||||||
Topological domain | 566-615 | Cytoplasmic | ||||
Sequence: PLVGIYKFVNARGNTISEKWQRVTMPYRKRPNQTEYIPIPTTQPHSDIML |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Significantly reduces the learned avoidance of bacteria that induce mitochondrial stress.
PTM/Processing
Features
Showing features for chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000214815 | 1-615 | Sodium-dependent dopamine transporter | |||
Sequence: MQLVPTDDPDEKIGRTSNGMQNATLPIDGPVNTEPKDPAREQWSGKLDFLLSVVGFAVDLGNIWRFPYLCFKNGGGVFLIPYSIMVLLTGVPLFYMELCLGQYYRKGAITTWGRICPLFKGIGYCVILTAFYVDFFYNVILAWGLHYLYTSFSFNLPWASCNNSYNSPACYEPHWSEDGTAMCRSANQSVSAEKISAAEEYFYKGFLGLHEANAPNSHVIRSVTDLGNVRWDIALSLFVVYLICYFSMWKGIHTSGKVVWFTALFPYVVLGILFIRGVTLPGWQNGIEYYLRPNFEMLKRPSVWQDAATQVFFSLGPGFGVLMAYSSYNDFHNNVYVDALFTSFINCATSFLSGFVIFSVLGYMSCKSGKPIEAVAQEGPGLVFVVYPEALSTMPYAPFWSVLFFLMLMTLGLDSSFGGSEAIITGLSDEFPILKKNREVFVGCLFAFYMVIGIAMCTEGGILIMEWLIIYGTTWGLLIAVFCEAMVIAYIYGLRQFVHDVKEMMGFRPGNYWKFCWSCAAPFILLSMITSNFINYQALTYQDYTYPTAANVIGIIFALSGASFIPLVGIYKFVNARGNTISEKWQRVTMPYRKRPNQTEYIPIPTTQPHSDIML | ||||||
Disulfide bond | 161↔170 | |||||
Sequence: CNNSYNSPAC | ||||||
Glycosylation | 162 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 187 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Family & Domains
Features
Showing features for region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-39 | Disordered | ||||
Sequence: MQLVPTDDPDEKIGRTSNGMQNATLPIDGPVNTEPKDPA |
Sequence similarities
Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length615
- Mass (Da)69,266
- Last updated2001-07-11 v3
- Checksum0DA2876EB3AC8049
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF079899 EMBL· GenBank· DDBJ | AAC83661.1 EMBL· GenBank· DDBJ | mRNA | ||
BX284603 EMBL· GenBank· DDBJ | CAA79575.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
Z19156 EMBL· GenBank· DDBJ | CAA79575.2 EMBL· GenBank· DDBJ | Genomic DNA |