Q035E5 · Q035E5_LACP3

Function

function

Fluoride-specific ion channel. Important for reducing fluoride concentration in the cell, thus reducing its toxicity.

Catalytic activity

Activity regulation

Na+ is not transported, but it plays an essential structural role and its presence is essential for fluoride channel function.

Features

Showing features for binding site.

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TypeIDPosition(s)Description
Binding site67Na+ (UniProtKB | ChEBI); structural
Binding site70Na+ (UniProtKB | ChEBI); structural

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular Functionfluoride channel activity
Molecular Functionmetal ion binding
Biological Processcellular detoxification of fluoride

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Fluoride-specific ion channel FluC

Gene names

    • Name
      fluC
    • Synonyms
      crcB
    • Ordered locus names
      LSEI_2441

Organism names

Accessions

  • Primary accession
    Q035E5

Proteomes

Subcellular Location

Cell membrane
; Multi-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane32-54Helical
Transmembrane60-83Helical
Transmembrane92-117Helical

Keywords

PTM/Processing

Proteomic databases

Interaction

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the fluoride channel Fluc/FEX (TC 1.A.43) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    118
  • Mass (Da)
    12,410
  • Last updated
    2006-11-14 v1
  • Checksum
    3D604AE4EAB3FE03
MVILIGIGAGLGAVCRYGITVLGKMFWPGKPLATLLINVLGSLLAGLLVGLPALSAFRLFLLPGFCGGFTTFSTFMADAFILIKNRRWSMAIFYYVGTVVAGLVAVVVGMMTSGILFA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CP000423
EMBL· GenBank· DDBJ
ABJ71177.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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