The CCL2/CCL7/CCL12/CCR2 pathway is substantially and persistently upregulated in mice after traumatic brain injury and CCL2 modulates the complement system in microglia.
FBXW7 degrades EZH2 and increases Ccl2/Ccl7 in CX3CR1hi macrophages which promotes the recruiting CX3CR1int pro-in fl ammatory mononuclear phagocytes into local colon tissues with colitis
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