Q03096 · EST3_YEAST

Function

function

Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromosome, telomeric region
Cellular Componentcytosol
Cellular Componentnucleus
Cellular Componenttelomerase holoenzyme complex
Molecular FunctionDNA/RNA helicase activity
Molecular FunctionGTPase activity
Molecular Functiontelomeric DNA binding
Biological Processtelomere maintenance via telomerase
Biological Processviral translational frameshifting

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Telomere replication protein EST3
  • Alternative names
    • Ever shorter telomeres protein 3

Gene names

    • Name
      EST3
    • Ordered locus names
      YIL009C-A

Organism names

Accessions

  • Primary accession
    Q03096
  • Secondary accessions
    • D6VVS0

Proteomes

Organism-specific databases

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis3Causes telomere shortening.
Mutagenesis21Causes telomere shortening.
Mutagenesis49Reduces ability to dimerize and causes telomere shortening.
Mutagenesis68Reduces ability to dimerize and causes telomere shortening.
Mutagenesis68Causes telomere shortening.
Mutagenesis71Causes telomere shortening, but does not impair interaction with the telomerase RNP.
Mutagenesis72Causes telomere shortening.
Mutagenesis82Causes telomere shortening.
Mutagenesis86Causes progressive telomere shortening and cell senescence.
Mutagenesis87Causes telomere shortening.
Mutagenesis95Causes telomere shortening.
Mutagenesis103Causes telomere shortening.
Mutagenesis104Reduces binding to DNA and RNA, and causes progressive telomere shortening and cell senescence.
Mutagenesis104Impairs interaction with the telomerase RNP and causes progressive telomere shortening and cell senescence.
Mutagenesis110Causes progressive telomere shortening and cell senescence, but does not impair interaction with the telomerase RNP.
Mutagenesis114Impairs interaction with the telomerase RNP and causes telomere shortening.
Mutagenesis115Impairs interaction with the telomerase RNP and causes telomere shortening.
Mutagenesis117Impairs interaction with the telomerase RNP and causes telomere shortening.
Mutagenesis164Causes telomere shortening, but does not impair interaction with the telomerase RNP.
Mutagenesis166Reduces ability to dimerize and causes telomere shortening.
Mutagenesis166Impairs interaction with the telomerase RNP and causes telomere shortening.
Mutagenesis168Causes telomere shortening.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 8 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000212061-181Telomere replication protein EST3

Proteomic databases

Interaction

Subunit

Homodimer. Component of the telomerase complex composed of EST1, EST2, EST3 and the RNA component TLC1. Interacts with the telomerase RNA component TLC1 in presence of EST2.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q03096EST2 Q061633EBI-6691, EBI-3764464

Protein-protein interaction databases

Miscellaneous

Family & Domains

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Ribosomal frameshifting.

Q03096-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Note
    Produced by ribosomal frameshifting between codon Leu-92 and Val-93.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    181
  • Mass (Da)
    20,555
  • Last updated
    2002-11-01 v2
  • Checksum
    18AF3DCEEE65DB84
MPKVILESHSKPTDSVFLQPWIKALIEDNSEHDQYHPSGHVIPSLTKQDLALPHMSPTILTNPCHFAKITKFYNVCDYKVYASIRDSSHQILVEFSQECVSNFERTHNCRITSETTNCLMIIGDADLVYVTNSRAMSHFKICLSNISSKEIVPVLNVNQATIFDIDQVGSLSTFPFVYKYL

Q03096-2

  • Name
    2
  • Note
    Produced from conventional translation of the YIL009C-A ORF. There is no apparent role for isoform 2 in the cell.
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_03581393in isoform 2
Alternative sequenceVSP_03581494-181in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
Z38113
EMBL· GenBank· DDBJ
CAA86240.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BK006942
EMBL· GenBank· DDBJ
DAA08536.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp