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Q02766 · COX1_PLAFA

  • Protein
    Cytochrome c oxidase subunit 1
  • Gene
    MT-CO1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    4/5

Function

function

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

Catalytic activity

Cofactor

Protein has several cofactor binding sites:
heme (UniProtKB | Rhea| CHEBI:30413 )

Note: Binds 2 heme A groups non-covalently per subunit.
Cu cation (UniProtKB | Rhea| CHEBI:23378 )

Note: Binds a copper B center.

Pathway

Energy metabolism; oxidative phosphorylation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site42Ca2+ (UniProtKB | ChEBI)
Binding site66Fe (UniProtKB | ChEBI) of Fe(II)-heme a (UniProtKB | ChEBI); low-spin; axial binding residue
Binding site246Cu cation B (UniProtKB | ChEBI)
Binding site250O2 (UniProtKB | ChEBI)
Binding site295Cu cation B (UniProtKB | ChEBI)
Binding site296Cu cation B (UniProtKB | ChEBI)
Binding site374Mg2+ (UniProtKB | ChEBI); ligand shared with subunit 2
Binding site375Mg2+ (UniProtKB | ChEBI); ligand shared with subunit 2
Binding site382Fe (UniProtKB | ChEBI) of heme a3 (UniProtKB | ChEBI); high-spin; axial binding residue
Binding site384Fe (UniProtKB | ChEBI) of Fe(II)-heme a (UniProtKB | ChEBI); low-spin; axial binding residue
Binding site448Ca2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentmitochondrial inner membrane
Cellular Componentrespiratory chain complex IV
Molecular Functioncytochrome-c oxidase activity
Molecular Functionheme binding
Molecular Functionmetal ion binding
Biological Processelectron transport coupled proton transport
Biological Processmitochondrial electron transport, cytochrome c to oxygen

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cytochrome c oxidase subunit 1
  • EC number
  • Alternative names
    • Cytochrome c oxidase polypeptide I

Gene names

    • Name
      MT-CO1
    • Synonyms
      COI, COXI, MTCO1

Encoded on

  • Mitochondrion

Organism names

  • Taxonomic identifier
  • Strain
    • MALAY CAMP
  • Taxonomic lineage
    Eukaryota > Sar > Alveolata > Apicomplexa > Aconoidasida > Haemosporida > Plasmodiidae > Plasmodium > Plasmodium (Laverania)

Accessions

  • Primary accession
    Q02766

Organism-specific databases

Subcellular Location

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane19-39Helical
Transmembrane61-81Helical
Transmembrane105-125Helical
Transmembrane151-171Helical
Transmembrane194-214Helical
Transmembrane240-260Helical
Transmembrane278-298Helical
Transmembrane310-330Helical
Transmembrane345-365Helical
Transmembrane379-399Helical
Transmembrane415-435Helical
Transmembrane455-475Helical

Keywords

PTM/Processing

Features

Showing features for chain, cross-link.

Type
IDPosition(s)Description
ChainPRO_00001833961-476Cytochrome c oxidase subunit 1
Cross-link246↔2501'-histidyl-3'-tyrosine (His-Tyr)

Interaction

Subunit

Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).

Structure

Family & Domains

Sequence similarities

Keywords

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    476
  • Mass (Da)
    52,729
  • Last updated
    1996-11-01 v1
  • MD5 Checksum
    BFDEBB827D3DD3585BD4367B2118966B
MVLNRYSLITNCNHKTLGLYYLWFSFLFGSYGFLLSVILRTELYSSSLRIIAQENVNLYNMIFTIHGIIMIFFNIMPGLFGGFGNYFLPILCGSPELAYPRINSISLLLQPIAFVLVILSTAAEFGGGTGWTLYPPLSTSLMSLSPVAVDVIIFGLLVSGVASIMSSLNFITTVMHLRAKGLTLGILSVSTWSLIITSGMLLLTLPVLTGGVLMLLSDLHFNTLFFDPTFAGDPILYQHLFWFFGHPEVYILILPAFGVISHVISTNYCRNLFGNQSMILAMGCIAVLGSLVWVHHMYTTGLEVDTRAYFTSTTILISIPTGTKVFNWICTYMSSNFGMIHSSSLLSLLFICTFTFGGTTGVILGNAAIDVALHDTYYVIAHFHFVLSIGAIIGLFTTVSAFQDNFFGKNLRENSIVILWSMLFFVGVILTFLPMHFLGFNVMPRRIPDYPDALNGWNMICSIGSTMTLFGLLIFK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M76611
EMBL· GenBank· DDBJ
AAC63390.2
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
M99416
EMBL· GenBank· DDBJ
AAC06269.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.

Similar Proteins

Disclaimer

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