Q02738 · CXB4_MOUSE
- ProteinGap junction beta-4 protein
- GeneGjb4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids266 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Structural component of gap junctions (PubMed:15692151).
Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).
Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151).
Gap junctions are dodecameric channels that connect the cytoplasm of adjoining cells. They are formed by the docking of two hexameric hemichannels, one from each cell membrane (By similarity).
Small molecules and ions diffuse from one cell to a neighboring cell via the central pore (PubMed:15692151).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | connexin complex | |
Cellular Component | nucleolus | |
Cellular Component | nucleoplasm | |
Cellular Component | plasma membrane | |
Molecular Function | gap junction channel activity | |
Biological Process | cell-cell signaling | |
Biological Process | gap junction-mediated intercellular transport | |
Biological Process | olfactory behavior | |
Biological Process | sensory perception of smell |
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameGap junction beta-4 protein
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ02738
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Note: Colocalizes with GJB2 at gap junction plaques in the cochlea.
Features
Showing features for intramembrane, topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Intramembrane | 2-13 | |||||
Sequence: NWGFLQGILSGV | ||||||
Topological domain | 14-20 | Cytoplasmic | ||||
Sequence: NKYSTAL | ||||||
Transmembrane | 21-40 | Helical | ||||
Sequence: GRIWLSVVFIFRVLVYVVAA | ||||||
Topological domain | 41-73 | Extracellular | ||||
Sequence: EEVWDDDQKDFICNTKQPGCPNVCYDEFFPVSH | ||||||
Transmembrane | 74-94 | Helical | ||||
Sequence: VRLWALQLILVTCPSLLVVMH | ||||||
Topological domain | 95-130 | Cytoplasmic | ||||
Sequence: VAYREERERKHRLKHGPNAPALYSNLSKKRGGLWWT | ||||||
Transmembrane | 131-151 | Helical | ||||
Sequence: YLLSLIFKAAVDSGFLYIFHC | ||||||
Topological domain | 152-184 | Extracellular | ||||
Sequence: IYKDYDMPRVVACSVTPCPHTVDCYIARPTEKK | ||||||
Transmembrane | 185-205 | Helical | ||||
Sequence: VFTYFMVVTAAICILLNLSEV | ||||||
Topological domain | 206-266 | Cytoplasmic | ||||
Sequence: VYLVGKRCMEVFRPRRRKASRRHQLPDTCPPYVISKGGHPQDESVILTKAGMATVDAGVYP |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000057866 | 1-266 | Gap junction beta-4 protein | |||
Sequence: MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVWDDDQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPNAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVTPCPHTVDCYIARPTEKKVFTYFMVVTAAICILLNLSEVVYLVGKRCMEVFRPRRRKASRRHQLPDTCPPYVISKGGHPQDESVILTKAGMATVDAGVYP | ||||||
Disulfide bond | 53↔175 | |||||
Sequence: CNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPNAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVTPCPHTVDC | ||||||
Disulfide bond | 60↔169 | |||||
Sequence: CPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPNAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVACSVTPC | ||||||
Disulfide bond | 64↔164 | |||||
Sequence: CYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERERKHRLKHGPNAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPRVVAC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Detected in cochlea (at protein level) (PubMed:15692151).
Detected in cochlea (PubMed:15692151).
Expressed in skin (PubMed:1512260).
Detected in cochlea (PubMed:15692151).
Expressed in skin (PubMed:1512260).
Developmental stage
Detected in cochlea after 15 dpc. Detected in the spiral limbus in neoneates at 2, 8 and 10 days after birth, before the onset of hearing.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length266
- Mass (Da)30,389
- Last updated1994-02-01 v1
- Checksum0772D708C004EFC1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M91443 EMBL· GenBank· DDBJ | AAA37428.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC064060 EMBL· GenBank· DDBJ | AAH64060.1 EMBL· GenBank· DDBJ | mRNA |