Q02455 · MLP1_YEAST

Function

function

Together with the closely related MLP2, involved in the structural and functional organization of perinuclear chromatin (PubMed:10638763).
Together with MLP2, associates with the nuclear pore complex and form filamentous structures along the nuclear periphery (PubMed:10085285, PubMed:24152732).
Has a role in the localization of Esc1 to nucleolar regions (PubMed:24152732).
Together with MLP2, mediates tethering of the some telomeres to the nuclear periphery, probably mediated by YKU70/YKU80 (HDF1/HDF2) heterodimer and show perinuclear location dependent silencing (PubMed:11862215).
MLP1 and MLP2 are involved in telomere length regulation but not silencing or telomere anchoring (PubMed:12490156).
Recognizes the 5'-splice site of pre-mRNAs and retains unspliced pre-mRNA in the nucleus without affecting splicing itself (PubMed:12490156, PubMed:12531921, PubMed:14718167).

Miscellaneous

Present with 2710 molecules/cell in log phase SD medium.

Caution

PubMed:8154186 misquoted the gene name as 'MPL1'.

GO annotations

AspectTerm
Cellular Componentnuclear envelope
Cellular Componentnuclear pore
Cellular Componentnuclear pore nuclear basket
Cellular Componentnucleoplasm
Molecular FunctionmRNA binding
Molecular Functionpromoter-terminator loop anchoring activity
Molecular Functionribonucleoprotein complex binding
Molecular Functionstructural constituent of nuclear pore
Biological ProcessDNA repair
Biological ProcessmRNA export from nucleus
Biological Processnegative regulation of protein import into nucleus during spindle assembly checkpoint
Biological Processnuclear mRNA surveillance
Biological Processnucleocytoplasmic transport
Biological Processpoly(A)+ mRNA export from nucleus
Biological Processprotein import into nucleus
Biological Processprotein localization to nuclear pore
Biological Processtelomere tethering at nuclear periphery

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein MLP1
  • Alternative names
    • Myosin-like protein 1

Gene names

    • Name
      MLP1
    • ORF names
      YKR415
    • Ordered locus names
      YKR095W

Organism names

Accessions

  • Primary accession
    Q02455
  • Secondary accessions
    • D6VXF5

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Distributed fairly evenly along a C-shaped portion of the nuclear periphery, where the spindle pole body localizes in 90% of the cases.

Keywords

PTM/Processing

Features

Showing features for initiator methionine, modified residue, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
Modified residue2N-acetylserine
ChainPRO_00000965012-1875Protein MLP1
Modified residue337Phosphothreonine
Modified residue379Phosphoserine
Modified residue1670Phosphoserine
Modified residue1710Phosphoserine
Modified residue1733Phosphoserine
Modified residue1803Phosphoserine

Post-translational modification

May be phosphorylated by CDC28.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Component of the nuclear pore complex (NPC) (PubMed:24152732).
NPC constitutes the exclusive means of nucleocytoplasmic transport (PubMed:24152732).
NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope (PubMed:24152732).
Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof (PubMed:24152732).
Interacts with NAB2, a hnRNP required for mRNA export (PubMed:12531921).
Interacts with MLP2 (PubMed:16027220).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q02455MLP2 P404573EBI-11009, EBI-25261
BINARY Q02455NAB2 P325054EBI-11009, EBI-11770

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for coiled coil, motif, region, compositional bias.

TypeIDPosition(s)Description
Coiled coil69-487
Coiled coil531-1678
Motif1496-1565Required for nuclear localization
Region1641-1690Disordered
Compositional bias1668-1689Polar residues
Compositional bias1716-1737Polar residues
Region1716-1875Disordered
Compositional bias1738-1752Basic and acidic residues
Compositional bias1766-1798Polar residues
Compositional bias1799-1875Basic and acidic residues
Coiled coil1834-1866

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,875
  • Mass (Da)
    218,456
  • Last updated
    1994-06-01 v2
  • Checksum
    683A0D34C9066867
MSDHDTPMESIQNGENSDERLNAIASFFGCSLEQVKSFDGDVVKHLNDKLLQFNELKSENLKVTVSFDELKASSLKKIDGLKTEMENVIRENDKIRKERNDTFVKFESVENEKMKLSSELEFVKRKLDDLTEEKKETQSNQQRTLKILDERLKEIELVRVENNRSNSECKKLRSTIMDLETKQQGYITNDLNSRTELERKTQELTLLQSNNDWLEKELRSKNEQYLSYRQKTDKVILDIRNELNRLRNDFQMERTNNDVLKQKNNELSKSLQEKLLEIKGLSDSLNSEKQEFSAEMSLKQRLVDLLESQLNAVKEELNSIRELNTAKVIADDSKKQTPENEDLLKELQLTKEKLAQCEKECLRLSSITDEADEDNENLSAKSSSDFIFLKKQLIKERRTKEHLQNQIETFIVELEHKVPIINSFKERTDMLENELNNAALLLEHTSNEKNAKVKELNAKNQKLVECENDLQTLTKQRLDLCRQIQYLLITNSVSNDSKGPLRKEEIQFIQNIMQEDDSTITESDSQKVVTERLVEFKNIIQLQEKNAELLKVVRNLADKLESKEKKSKQSLQKIESETVNEAKEAIITLKSEKMDLESRIEELQKELEELKTSVPNEDASYSNVTIKQLTETKRDLESQVQDLQTRISQITRESTENMSLLNKEIQDLYDSKSDISIKLGKEKSSRILAEERFKLLSNTLDLTKAENDQLRKRFDYLQNTILKQDSKTHETLNEYVSCKSKLSIVETELLNLKEEQKLRVHLEKNLKQELNKLSPEKDSLRIMVTQLQTLQKEREDLLEETRKSCQKKIDELEDALSELKKETSQKDHHIKQLEEDNNSNIEWYQNKIEALKKDYESVITSVDSKQTDIEKLQYKVKSLEKEIEEDKIRLHTYNVMDETINDDSLRKELEKSKINLTDAYSQIKEYKDLYETTSQSLQQTNSKLDESFKDFTNQIKNLTDEKTSLEDKISLLKEQMFNLNNELDLQKKGMEKEKADFKKRISILQNNNKEVEAVKSEYESKLSKIQNDLDQQTIYANTAQNNYEQELQKHADVSKTISELREQLHTYKGQVKTLNLSRDQLENALKENEKSWSSQKESLLEQLDLSNSRIEDLSSQNKLLYDQIQIYTAADKEVNNSTNGPGLNNILITLRRERDILDTKVTVAERDAKMLRQKISLMDVELQDARTKLDNSRVEKENHSSIIQQHDDIMEKLNQLNLLRESNITLRNELENNNNKKKELQSELDKLKQNVAPIESELTALKYSMQEKEQELKLAKEEVHRWKKRSQDILEKHEQLSSSDYEKLESEIENLKEELENKERQGAEAEEKFNRLRRQAQERLKTSKLSQDSLTEQVNSLRDAKNVLENSLSEANARIEELQNAKVAQGNNQLEAIRKLQEDAEKASRELQAKLEESTTSYESTINGLNEEITTLKEEIEKQRQIQQQLQATSANEQNDLSNIVESMKKSFEEDKIKFIKEKTQEVNEKILEAQERLNQPSNINMEEIKKKWESEHEQEVSQKIREAEEALKKRIRLPTEEKINKIIERKKEELEKEFEEKVEERIKSMEQSGEIDVVLRKQLEAKVQEKQKELENEYNKKLQEELKDVPHSSHISDDERDKLRAEIESRLREEFNNELQAIKKKSFDEGKQQAMMKTTLLERKLAKMESQLSETKQSAESPPKSVNNVQNPLLGLPRKIEENSNSPFNPLLSGEKLLKLNSKSSSGGFNPFTSPSPNKHLQNDNDKRESLANKTDPPTHLEPSFNIPASRGLISSSSTLSTDTNDEELTSNNPAQKDSSNRNVQSEEDTEKKKEGEPVKRGEAIEEQTKSNKRPIDEVGELKNDEDDTTENINESKKIKTEDEEEKETDKVNDENSI

Features

Showing features for sequence conflict, compositional bias.

TypeIDPosition(s)Description
Sequence conflict301in Ref. 1; AAA34783
Compositional bias1668-1689Polar residues
Compositional bias1716-1737Polar residues
Compositional bias1738-1752Basic and acidic residues
Compositional bias1766-1798Polar residues
Compositional bias1799-1875Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L01992
EMBL· GenBank· DDBJ
AAA34783.1
EMBL· GenBank· DDBJ
Genomic DNA
X73541
EMBL· GenBank· DDBJ
CAA51948.1
EMBL· GenBank· DDBJ
Genomic DNA
Z28320
EMBL· GenBank· DDBJ
CAA82174.1
EMBL· GenBank· DDBJ
Genomic DNA
BK006944
EMBL· GenBank· DDBJ
DAA09245.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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