Q02293 · FNTB_RAT

  • Protein
    Protein farnesyltransferase subunit beta
  • Gene
    Fntb
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Features

Showing features for site, binding site.

143750100150200250300350400
TypeIDPosition(s)Description
Site102Important for selectivity against geranylgeranyl diphosphate
Binding site248-251(2E,6E)-farnesyl diphosphate (UniProtKB | ChEBI)
Binding site291-294(2E,6E)-farnesyl diphosphate (UniProtKB | ChEBI)
Binding site297Zn2+ (UniProtKB | ChEBI); catalytic
Binding site299Zn2+ (UniProtKB | ChEBI); catalytic
Binding site300-303(2E,6E)-farnesyl diphosphate (UniProtKB | ChEBI)
Binding site362Zn2+ (UniProtKB | ChEBI); catalytic

GO annotations

AspectTerm
Cellular Componentmicrotubule associated complex
Cellular Componentprotein farnesyltransferase complex
Molecular Functionfarnesyltranstransferase activity
Molecular Functionprotein farnesyltransferase activity
Molecular Functionzinc ion binding
Biological Processcell population proliferation
Biological Processfibroblast proliferation
Biological Processlipid metabolic process
Biological Processnegative regulation of cell population proliferation
Biological Processpositive regulation of cell cycle
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of fibroblast proliferation
Biological Processpositive regulation of nitric-oxide synthase biosynthetic process
Biological Processprotein farnesylation
Biological Processregulation of fibroblast proliferation
Biological Processresponse to cytokine
Biological Processresponse to organic cyclic compound
Biological Processwound healing

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein farnesyltransferase subunit beta
  • EC number
  • Short names
    FTase-beta
  • Alternative names
    • CAAX farnesyltransferase subunit beta
    • Ras proteins prenyltransferase subunit beta

Gene names

    • Name
      Fntb

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q02293

Proteomes

Organism-specific databases

Phenotypes & Variants

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001197631-437Protein farnesyltransferase subunit beta
Modified residue432Phosphoserine
Modified residue436Phosphothreonine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Heterodimer of FNTA and FNTB.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q02293Fnta Q0463116EBI-602454, EBI-602447
View interactors in UniProtKB
View CPX-2181 in Complex Portal

Protein-protein interaction databases

Chemistry

Family & Domains

Features

Showing features for repeat.

TypeIDPosition(s)Description
Repeat123-164PFTB 1
Repeat174-215PFTB 2
Repeat222-263PFTB 3
Repeat270-312PFTB 4
Repeat332-374PFTB 5

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    437
  • Mass (Da)
    48,673
  • Last updated
    1993-04-01 v1
  • Checksum
    41A9D6D79CD319A8
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVMGVPENVLQPTHPVYNIGPDKVIQATTHFLQKPVPGFEECEDAVTSDPATD

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6GKJ2A0A8I6GKJ2_RATChurc178
A0A8I6GKV7A0A8I6GKV7_RATChurc135
B5DER2B5DER2_RATChurc1112
A0A8I5ZMQ9A0A8I5ZMQ9_RATFntb408
A0A8I5ZP53A0A8I5ZP53_RATChurc1104
A0A8I5ZQQ4A0A8I5ZQQ4_RATChurc1471

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M69056
EMBL· GenBank· DDBJ
AAA41176.1
EMBL· GenBank· DDBJ
mRNA
BC087675
EMBL· GenBank· DDBJ
AAH87675.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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