Q02115 · TAGU_BACSU

  • Protein
    Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU
  • Gene
    tagU
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May catalyze the final step in cell wall teichoic acid biosynthesis, the transfer of the anionic cell wall polymers (APs) from their lipid-linked precursor to the cell wall peptidoglycan (PG).

Caution

Was originally thought to be involved in transcriptional regulation.
This protein is unrelated to LytR from S.aureus, which is part of a two-component regulatory system that, together with LytS, is involved in autolysis and cell wall metabolism. The B.subtilis ortholog of S.aureus LytR is LytT (AC P94514).

Pathway

Cell wall biogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane raft
Cellular Componentplasma membrane
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological Processcell wall assembly

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU
  • EC number
  • Alternative names
    • Membrane-bound protein LytR

Gene names

    • Name
      tagU
    • Synonyms
      lytR
    • Ordered locus names
      BSU35650

Organism names

Accessions

  • Primary accession
    Q02115

Proteomes

Subcellular Location

Cell membrane
; Single-pass type II membrane protein
Membrane raft
; Single-pass type II membrane protein
Note: Present in detergent-resistant membrane (DRM) fractions that may be equivalent to eukaryotic membrane rafts; these rafts include proteins involved in signaling, molecule trafficking and protein secretion.

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1-11Cytoplasmic
Transmembrane12-32Helical; Signal-anchor for type II membrane protein
Topological domain33-306Extracellular

Keywords

Phenotypes & Variants

Disruption phenotype

Single mutant has no effect on cell growth or morphology under normal growth conditions. Triple disruption of tagTUV genes is not viable (PubMed:21964069).
Cells lacking this gene display a considerably increased transcription frequency of lytR and lytABC operon expression (PubMed:1357079).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis75Does not complement the tagTUV deletion mutant.
Mutagenesis83Does not complement the tagTUV deletion mutant.
Mutagenesis85Does not complement the tagTUV deletion mutant.
Mutagenesis86Does not complement the tagTUV deletion mutant.
Mutagenesis197Does not complement the tagTUV deletion mutant.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002184981-306Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU

Proteomic databases

Interaction

Subunit

Interacts with MreB (PubMed:21964069).
Interacts with FloT (PubMed:23651456).

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the LytR/CpsA/Psr (LCP) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    306
  • Mass (Da)
    34,586
  • Last updated
    1993-07-01 v1
  • Checksum
    E79BE5DDFFA3B089
MRNERRKKKKTLLLTILTIIGLLVLGTGGYAYYLWHKAASTVASIHESIDKSKKRDKEVSINKKDPFSVLIMGVDERDGDKGRADTLIYMTVNPKTNTTDMVSIPRDTYTKIIGKGTMDKINHSYAFGGTQMTVDTVENFLDVPVDYFVKVNMESFRDVVDTLGGITVNSTFAFSYDGYSFGKGEITLNGKEALAYTRMRKEDPRGDFGRQDRQRQVIQGIINKGANISSITKFGDMFKVVENNVKTNLTFDNMWDIQSDYKGARKHIKQHELKGTGTKINGIYYYQADESALSDITKELKESLEK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M87645
EMBL· GenBank· DDBJ
AAA22578.1
EMBL· GenBank· DDBJ
Genomic DNA
AL009126
EMBL· GenBank· DDBJ
CAB15582.1
EMBL· GenBank· DDBJ
Genomic DNA
Z22516
EMBL· GenBank· DDBJ
CAA80239.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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