Q01819 · CONN_DROME
- ProteinConnectin
- GeneCon
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids682 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Cell adhesion protein involved in target recognition during neuromuscular development. Mediates homophilic cellular adhesion.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | axonal growth cone | |
Cellular Component | cell surface | |
Cellular Component | neuromuscular junction | |
Cellular Component | plasma membrane | |
Cellular Component | side of membrane | |
Biological Process | axonal fasciculation | |
Biological Process | homophilic cell adhesion via plasma membrane adhesion molecules | |
Biological Process | synaptic target attraction |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameConnectin
Gene names
Organism names
- Strains
- Taxonomic lineageEukaryota > Metazoa > Ecdysozoa > Arthropoda > Hexapoda > Insecta > Pterygota > Neoptera > Endopterygota > Diptera > Brachycera > Muscomorpha > Ephydroidea > Drosophilidae > Drosophila > Sophophora
Accessions
- Primary accessionQ01819
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for signal, chain, lipidation, propeptide.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-24 | |||||
Sequence: MATLADSAICFLLLSLLLIGACLV | ||||||
Chain | PRO_0000020979 | 25-658 | Connectin | |||
Sequence: TPTEGRAKDDRRTRGRGSSSGVLSSSSSSSNNMNNGYYSGSSSTAGSSSGYVFTSSSAVNSGSTGYSGPMDSTGFCTRRRDMKLMCYCTPDENHVPVQKAECWVFSEGLHQNDTTWTRFYQQKRLRELKFVIQNNARLDYIPTMIIEPLKNLSSIVIEYSQVEIVKSYAFANLPFLERIILNNNHIMALDQDAFANHIRLRELNLEHNQIFEMDRYAFRNLPLCERLFLNNNNISTLHEGLFADMARLTFLNLAHNQINVLTSEIFRGLGNLNVLKLTRNNLNFIGDTVFAELWSLSELELDDNRIERISERALDGLNTLKTLNLRNNLLKKIDNGLLRGTPALLSINVQANKLETLTFYTFQPIMDNLVNSTSELLVSDNKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVLNIGGFTAIGSNSASMGGVGNSVVGSSYSGLTMDDSRKHLGSRSRQALRGQRQFASSAENVVESKMRRRRKRQEEVKEKDLAAVAPAHKRYDYYDDNNGGMSLGHGLDLDDNLSLHKQGFYGAGSPVVGHNDVDVLMTSHSASGDALDILTTKNAIYIKLFLLKPEMLPCHDELSDPTELPLSRDLMDVRSNVGQDMSTA | ||||||
Lipidation | 658 | GPI-anchor amidated alanine | ||||
Sequence: A | ||||||
Propeptide | PRO_0000020980 | 659-682 | Removed in mature form | |||
Sequence: GANSLAQGMTIIVSLVALMMISRG |
Keywords
- PTM
Proteomic databases
Expression
Tissue specificity
Predominantly expressed in abdominal and thoracic segment muscle and motorneuron cells.
Developmental stage
Embryo.
Gene expression databases
Structure
Family & Domains
Features
Showing features for region, repeat, domain, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 29-54 | Disordered | ||||
Sequence: GRAKDDRRTRGRGSSSGVLSSSSSSS | ||||||
Repeat | 149-172 | LRR 1 | ||||
Sequence: LRELKFVIQNNARLDYIPTMIIEP | ||||||
Repeat | 173-196 | LRR 2 | ||||
Sequence: LKNLSSIVIEYSQVEIVKSYAFAN | ||||||
Repeat | 199-220 | LRR 3 | ||||
Sequence: FLERIILNNNHIMALDQDAFAN | ||||||
Repeat | 223-244 | LRR 4 | ||||
Sequence: RLRELNLEHNQIFEMDRYAFRN | ||||||
Repeat | 247-268 | LRR 5 | ||||
Sequence: LCERLFLNNNNISTLHEGLFAD | ||||||
Repeat | 271-292 | LRR 6 | ||||
Sequence: RLTFLNLAHNQINVLTSEIFRG | ||||||
Repeat | 295-316 | LRR 7 | ||||
Sequence: NLNVLKLTRNNLNFIGDTVFAE | ||||||
Repeat | 319-342 | LRR 8 | ||||
Sequence: SLSELELDDNRIERISERALDGLN | ||||||
Repeat | 343-364 | LRR 9 | ||||
Sequence: TLKTLNLRNNLLKKIDNGLLRG | ||||||
Repeat | 367-388 | LRR 10 | ||||
Sequence: ALLSINVQANKLETLTFYTFQP | ||||||
Repeat | 389-404 | LRR 11 | ||||
Sequence: IMDNLVNSTSELLVSD | ||||||
Domain | 405-462 | LRRCT | ||||
Sequence: NKFICDCRLQWIFELKNRTRHLQLRDSLEDLHCTLQEPKLSHFVDPVPPTILDVLNIG | ||||||
Region | 503-536 | Disordered | ||||
Sequence: RQALRGQRQFASSAENVVESKMRRRRKRQEEVKE | ||||||
Compositional bias | 504-518 | Polar residues | ||||
Sequence: QALRGQRQFASSAEN | ||||||
Compositional bias | 520-536 | Basic and acidic residues | ||||
Sequence: VESKMRRRRKRQEEVKE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length682
- Mass (Da)75,995
- Last updated2004-05-10 v2
- ChecksumE7F26353438ED06F
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q6AWM0 | Q6AWM0_DROME | Con | 691 |
Sequence caution
Features
Showing features for compositional bias, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 504-518 | Polar residues | ||||
Sequence: QALRGQRQFASSAEN | ||||||
Compositional bias | 520-536 | Basic and acidic residues | ||||
Sequence: VESKMRRRRKRQEEVKE | ||||||
Sequence conflict | 631 | in Ref. 2; CAA48652 | ||||
Sequence: E → G | ||||||
Sequence conflict | 674-677 | in Ref. 1; AAA28424 | ||||
Sequence: VALM → QVAL |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
M96647 EMBL· GenBank· DDBJ | AAA28424.1 EMBL· GenBank· DDBJ | mRNA | ||
X68701 EMBL· GenBank· DDBJ | CAA48652.1 EMBL· GenBank· DDBJ | mRNA | ||
AE014296 EMBL· GenBank· DDBJ | AAF47952.3 EMBL· GenBank· DDBJ | Genomic DNA | Different initiation | |
AY119518 EMBL· GenBank· DDBJ | AAM50172.1 EMBL· GenBank· DDBJ | mRNA | Different initiation |