Q01782 · PTR1_LEIMA
- ProteinPteridine reductase 1
- GenePTR1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids288 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Exhibits a NADPH-dependent biopterin reductase activity. Has good activity with folate and significant activity with dihydrofolate and dihydrobiopterin, but not with quinonoid dihydrobiopterin. Confers resistance to methotrexate (MTX).
Catalytic activity
- (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + 2 NADP+ = 2 H+ + L-erythro-biopterin + 2 NADPH
Pathway
Cofactor biosynthesis; tetrahydrobiopterin biosynthesis; tetrahydrobiopterin from biopterin: step 1/1.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | 6,7-dihydropteridine reductase activity | |
Molecular Function | oxidoreductase activity | |
Molecular Function | pteridine reductase activity | |
Biological Process | response to methotrexate | |
Biological Process | tetrahydrobiopterin biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePteridine reductase 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Discoba > Euglenozoa > Kinetoplastea > Metakinetoplastina > Trypanosomatida > Trypanosomatidae > Leishmaniinae > Leishmania
Accessions
- Primary accessionQ01782
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000054753 | 1-288 | Pteridine reductase 1 | |||
Sequence: MTAPTVPVALVTGAAKRLGRSIAEGLHAEGYAVCLHYHRSAAEANALSATLNARRPNSAITVQADLSNVATAPVSGADGSAPVTLFTRCAELVAACYTHWGRCDVLVNNASSFYPTPLLRNDEDGHEPCVGDREAMETATADLFGSNAIAPYFLIKAFAHRFAGTPAKHRGTNYSIINMVDAMTNQPLLGYTIYTMAKGALEGLTRSAALELAPLQIRVNGVGPGLSVLVDDMPPAVWEGHRSKVPLYQRDSSAAEVSDVVIFLCSSKAKYITGTCVKVDGGYSLTRA |
Structure
Sequence
- Sequence statusComplete
- Length288
- Mass (Da)30,457
- Last updated2002-05-27 v2
- ChecksumB8F6FC23018367E0
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 162 | in Ref. 3; CAJ03998 | ||||
Sequence: F → V |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
L01699 EMBL· GenBank· DDBJ | AAA29249.2 EMBL· GenBank· DDBJ | Genomic DNA | ||
FR796419 EMBL· GenBank· DDBJ | CAJ03998.1 EMBL· GenBank· DDBJ | Genomic DNA |