Q01638 · ILRL1_HUMAN
- ProteinInterleukin-1 receptor-like 1
- GeneIL1RL1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids556 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8. Possibly involved in helper T-cell function (Probable) (PubMed:16286016).
Upon tissue injury, induces UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity).
Isoform B
Catalytic activity
- H2O + NAD+ = ADP-D-ribose + H+ + nicotinamideThis reaction proceeds in the forward direction.
Features
Showing features for active site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Active site | 461 | |||||
Sequence: E |
GO annotations
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameInterleukin-1 receptor-like 1
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ01638
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 19-328 | Extracellular | ||||
Sequence: KFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHS | ||||||
Transmembrane | 329-349 | Helical | ||||
Sequence: IYCIIAVCSVFLMLINVLVII | ||||||
Topological domain | 350-556 | Cytoplasmic | ||||
Sequence: LKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ |
Keywords
- Cellular component
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_023749 | 78 | in dbSNP:rs1041973 | |||
Sequence: A → E | ||||||
Natural variant | VAR_053373 | 433 | in dbSNP:rs4988956 | |||
Sequence: A → T | ||||||
Natural variant | VAR_053374 | 501 | in dbSNP:rs10192036 | |||
Sequence: Q → K | ||||||
Natural variant | VAR_053375 | 501 | in dbSNP:rs10204137 | |||
Sequence: Q → R | ||||||
Natural variant | VAR_053376 | 549 | in dbSNP:rs10192157 | |||
Sequence: T → I | ||||||
Natural variant | VAR_053377 | 551 | in dbSNP:rs10206753 | |||
Sequence: L → S |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 790 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-18 | |||||
Sequence: MGFWILAILTILMYSTAA | ||||||
Chain | PRO_0000015442 | 19-556 | Interleukin-1 receptor-like 1 | |||
Sequence: KFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRKNPIDHHSIYCIIAVCSVFLMLINVLVIILKMFWIEATLLWRDIAKPYKTRNDGKLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQMPVPSKIPRKASSLTPLAAQKQ | ||||||
Disulfide bond | 36↔87 | |||||
Sequence: CPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTC | ||||||
Glycosylation | 54 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 95 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 101 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 111↔151 | |||||
Sequence: CNVPDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNC | ||||||
Disulfide bond | 133↔181 | |||||
Sequence: CPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTC | ||||||
Glycosylation | 140 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 191 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 232 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 235↔303 | |||||
Sequence: CSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDC | ||||||
Disulfide bond | 238↔282 | |||||
Sequence: CFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLAC | ||||||
Glycosylation | 254 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 273 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Cross-link | 321 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | ||||
Sequence: K |
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Gene expression databases
Organism-specific databases
Interaction
Subunit
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain, region.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 19-103 | Ig-like C2-type 1 | ||||
Sequence: KFSKQSWGLENEALIVRCPRQGKPSYTVDWYYSQTNKSIPTQERNRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGYANVT | ||||||
Domain | 114-197 | Ig-like C2-type 2 | ||||
Sequence: PDYLMYSTVSGSEKNSKIYCPTIDLYNWTAPLEWFKNCQALQGSRYRAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTAT | ||||||
Region | 198-211 | Flexible linker | ||||
Sequence: RSFTVKDEQGFSLF | ||||||
Domain | 212-319 | Ig-like C2-type 3 | ||||
Sequence: PVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQNQSFSNGLACLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLS | ||||||
Domain | 375-535 | TIR | ||||
Sequence: KLYDAYVVYPRNYKSSTDGASRVEHFVHQILPDVLENKCGYTLCIYGRDMLPGEDVVTAVETNIRKSRRHIFILTPQITHNKEFAYEQEVALHCALIQNDAKVILIEMEALSELDMLQAEALQDSLQHLMKVQGTIKWREDHIANKRSLNSKFWKHVRYQM |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 4 isoforms produced by Alternative splicing.
Q01638-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- NameA
- SynonymsST2L
- Length556
- Mass (Da)63,358
- Last updated2006-10-17 v4
- ChecksumCB3E444A2DD477B5
Q01638-2
- NameB
- SynonymsST2S
Q01638-3
- NameC
- SynonymsST2V
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Q01638-4
- Name4
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_054933 | 1-117 | in isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 70 | in Ref. 2; BAA85894 | ||||
Sequence: Q → R | ||||||
Alternative sequence | VSP_002664 | 204-259 | in isoform C | |||
Sequence: DEQGFSLFPVIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKIT → VWCQSFCKLKKSLIFSNTHWIQSLMRGFVMVYYGVHKCCRVVFNLCLQYFQHHQWP | ||||||
Alternative sequence | VSP_002665 | 260-556 | in isoform C | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_002666 | 324-328 | in isoform B and isoform 4 | |||
Sequence: IDHHS → SKECF | ||||||
Alternative sequence | VSP_002667 | 329-556 | in isoform B and isoform 4 | |||
Sequence: Missing |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
D12763 EMBL· GenBank· DDBJ | BAA02233.1 EMBL· GenBank· DDBJ | mRNA | ||
D12764 EMBL· GenBank· DDBJ | BAA20539.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AB029084 EMBL· GenBank· DDBJ | BAA85894.1 EMBL· GenBank· DDBJ | mRNA | ||
AB012701 EMBL· GenBank· DDBJ | BAA82405.2 EMBL· GenBank· DDBJ | mRNA | ||
AK291578 EMBL· GenBank· DDBJ | BAF84267.1 EMBL· GenBank· DDBJ | mRNA | ||
AK303389 EMBL· GenBank· DDBJ | BAG64445.1 EMBL· GenBank· DDBJ | mRNA | ||
AC007248 EMBL· GenBank· DDBJ | AAY15047.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CH471127 EMBL· GenBank· DDBJ | EAX01795.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC030975 EMBL· GenBank· DDBJ | AAH30975.1 EMBL· GenBank· DDBJ | mRNA |