Q01397 · DYNA_NEUCR

Function

function

Required for the cytoplasmic dynein-driven retrograde movement of vesicles and organelles along microtubules. Dynein-dynactin interaction is a key component of the mechanism of axonal transport of vesicles and organelles (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell tip
Cellular Componentcytoplasm
Cellular Componentdynein complex
Cellular Componentmicrotubule
Cellular Componentmicrotubule associated complex
Cellular Componentspindle
Cellular Componentspindle pole body
Biological Processestablishment of mitotic spindle orientation
Biological Processnuclear migration involved in conjugation with cellular fusion

Names & Taxonomy

Protein names

  • Recommended name
    Dynactin, 150 kDa isoform
  • Alternative names
    • 150 kDa dynein-associated polypeptide (DAP-150; DP-150)
    • p150-glued

Gene names

    • Name
      ro-3
    • ORF names
      B8L21.160, NCU03483

Organism names

Accessions

  • Primary accession
    Q01397
  • Secondary accessions
    • Q7RV43
    • Q8WZS2

Proteomes

    • Identifier
    • Component
      Chromosome 6, Linkage Group II

Organism-specific databases

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000835241-1367Dynactin, 150 kDa isoform

Proteomic databases

Interaction

Subunit

Large macromolecular complex of at least 10 components; p150(glued) binds directly to microtubules and to cytoplasmic dynein.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, compositional bias, region, coiled coil.

TypeIDPosition(s)Description
Domain28-70CAP-Gly
Compositional bias76-90Pro residues
Region76-318Disordered
Compositional bias91-108Polar residues
Compositional bias132-215Polar residues
Compositional bias226-271Polar residues
Compositional bias302-318Polar residues
Coiled coil321-598
Coiled coil637-698
Coiled coil1039-1199

Sequence similarities

Belongs to the dynactin 150 kDa subunit family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,367
  • Mass (Da)
    152,097
  • Last updated
    2007-12-04 v3
  • Checksum
    647A99C674131564
MSELGVAVGQKIELADGSGRTAFVRYVGETAFAPGTWVGIELDEPSGKNDGSVQGERYFNCEMGYGMFVRPTTFNVIAQPPPPPPPSTFRRSVTTRPTSLNASTTRRPAPVDSGLAKRMSLNAPSPSPGPRPSRTSSTSITRSPTRSPTKQLATASSSGNPSRSGTPSTTTKPAGPTTRTRPSLSTSRHSMGPPPTPTTRTTRKPSVSSVGTRPSIGATRPVGGRASMSARSSTNRLSDPRESTGSVSSVGKSGFKRGSASPRSSDEELSASPVPASPVHQKTAALEKLTAPGAGNGGGGASPGATSPNLKATTITPRSSITNTATMNKEIEDLKAKLKVLEKKRMEDREKLNSLEKVKAERDKFERIIQTLQIKYQPQQQEIQDLKRQLKEAENRLYNVEELQAEHDTAMELATLDREMAEETAEVLKVELDALKQKNEELELEVEVLREENSEFTNGMSPEERASTGWLQMERNNERLREALIRLRDITQQQEEELKDQIKSMEEDLREFETIKEQHTTAKEKLAQTEAIVEDLREQLNNALGAEEIIESLTEQTMNQSEEIKELRAVIDDLESLKEINDELEINHVQNEKEMQEEIDLKDSIIAEQFRQANLQRESLEDMEYTLSRFRELVTSLQSDLEDMRASHAVTENESEQLNSRSRAMLDLNMKLQISASKAQVKTIDLELRRMEAQEAEQHLEIVKLFLPDTYQSDRDSVLALLRFKRLAFKANLLNGFIKERVNGQPHPGHEDDIFDGCDAIDKLTWVSAMCDRFVNAISHCSLEQFSRYEGALYELEPVERALNGWIDGLRRDDLKEKQCADELKRTIALMTHLGEVHISNDLESFADDVHMKALLMQSHLESAAISVNSLKAMVQRVIPSSGEDDELAQYFSKRAEAVVSQTRSAKVIAGKTVRALEDLKTRSLSLTPDTLEAFEQSETATRDLANMARQIGLDLHAFLHEEGRTEPYNYMEVQSCIQRSAQASSPTASSPESDLFNTYLSYLRNATSTISDLASLASDLAQTQEFDRTPAPWILRSAELKAAKTVAPDINDELRRLRDDIAEARRSIAVREEMLSTAQVKIETLESRMRDANAKAARIVDLEADLQAAKKEAAQLQEDMEKQDRELKALESDRDKWKKIASESRVVVADGSGVGVDNKASAERAVATAREMDALKKEIEALQAAVRYLREDSRRARLKEQGDYEWLAEPLVKKKPSVQEQRKQLVKKEGKAVLGELVKLVSSAKVFDLGSLPEKAEDRLKWRPAKTTPGWWVAKQMEDWEALKEWEGSVKGRVRELGGVPGSKKAEREEEAKRMVRRTAAAKLQIRLPGMEGKVGHGGGGGSGRRVQIVGSREWESLQGRLAVVV

Sequence caution

The sequence AAA80458.1 differs from that shown. Reason: Erroneous gene model prediction
The sequence CAD21101.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias76-90Pro residues
Compositional bias91-108Polar residues
Compositional bias132-215Polar residues
Compositional bias226-271Polar residues
Compositional bias302-318Polar residues
Sequence conflict1172in Ref. 1; AAA80458

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L48661
EMBL· GenBank· DDBJ
AAA80458.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AL669989
EMBL· GenBank· DDBJ
CAD21101.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
CM002237
EMBL· GenBank· DDBJ
EAA26534.2
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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