Q01248 · YSCG_YEREN

  • Protein
    Type 3 secretion system chaperone YscG
  • Gene
    yscG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    3/5

Function

function

Chaperone of the type III secretion system (T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (By similarity).
Along with YscE, prevents premature polymerization of the YscF/SctF needle protein within the cytoplasm (By similarity).
Required for Yop secretion (PubMed:8709853).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Type 3 secretion system chaperone YscG
  • Alternative names
    • Yersinia secretion component G
    • Yop proteins translocation protein G

Gene names

    • Name
      yscG

Encoded on

  • Plasmid pYV

Organism names

  • Taxonomic identifier
  • Strain
    • 439-80 / Serotype O:9
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Yersiniaceae > Yersinia

Accessions

  • Primary accession
    Q01248

Subcellular Location

Cytoplasm
Note: Could be a peripheral membrane protein.

Keywords

Phenotypes & Variants

Disruption phenotype

The yscFG double mutant is unable to secrete the Yop proteins upon thermal induction in a Ca2+-deprived medium.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000664821-115Type 3 secretion system chaperone YscG

Expression

Induction

At 37 degrees Celsius in the absence of calcium (PubMed:1860816).
Belongs to an operon involved in the translocation of Yop proteins across the bacterial membranes or in the specific control of this function (PubMed:1860816).

Interaction

Subunit

Component of the heterodimeric YscE-YscG chaperone (By similarity).
The YscE-YscG chaperone forms a stable ternary complex with YscF/SctF (By similarity).

Structure

Family & Domains

Sequence similarities

Belongs to the YscG family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    115
  • Mass (Da)
    12,930
  • Last updated
    1993-04-01 v1
  • Checksum
    64C2EE2629174EF2
MKYKLNVLLAEIALIGTGNHCHEEANCIAEWLHLKGEEEAVQLIQLSSLMNRGDYASALQQGNKSTYPDLEPWLALCEYRLGLGNALESRLNRLATSQDPRIQTFVNGMKEQLKT

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M74011
EMBL· GenBank· DDBJ
AAC37024.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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