Q01206 · POL1_BAYMJ

Function

function

6 kDa protein 1

Indispensable for virus replication.

6 kDa protein 2

Indispensable for virus replication.

Viral genome-linked protein

Mediates the cap-independent, EIF4E-dependent translation of viral genomic RNAs (By similarity).
Binds to the cap-binding site of host EIF4E and thus interferes with the host EIF4E-dependent mRNA export and translation (By similarity).
VPg-RNA directly binds EIF4E and is a template for transcription (By similarity).
Also forms trimeric complexes with EIF4E-EIF4G, which are templates for translation (By similarity).

Nuclear inclusion protein A

Has RNA-binding and proteolytic activities.

Nuclear inclusion protein B

An RNA-dependent RNA polymerase that plays an essential role in the virus replication.

Catalytic activity

Features

Showing features for site, binding site, active site.

TypeIDPosition(s)Description
Site328-329Cleavage
Site394-395Cleavage
Binding site487-494ATP (UniProtKB | ChEBI)
Site1053-1054Cleavage
Site1175-1176Cleavage
Site1338-1339Cleavage
Active site1404For nuclear inclusion protein A activity
Active site1440For nuclear inclusion protein A activity
Active site1507For nuclear inclusion protein A activity
Site1586-1587Cleavage
Site2114-2115Cleavage

GO annotations

AspectTerm
Cellular Componenthelical viral capsid
Cellular Componenthost cell cytoplasmic vesicle
Molecular FunctionATP binding
Molecular Functioncysteine-type peptidase activity
Molecular Functionhelicase activity
Molecular Functionhydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides
Molecular FunctionRNA binding
Molecular FunctionRNA-dependent RNA polymerase activity
Molecular Functionstructural molecule activity
Biological ProcessDNA-templated transcription
Biological Processproteolysis
Biological Processviral RNA genome replication

Keywords

Names & Taxonomy

Protein names

Organism names

Accessions

  • Primary accession
    Q01206

Proteomes

Subcellular Location

6 kDa protein 1

Note: Probably colocalizes with 6K2-induced vesicles associated with host chloroplasts.

6 kDa protein 2

Note: 6K-induced vesicles associate with host chloroplasts.

Coat protein

Virion

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000405461-328Protein P3
ChainPRO_00004562441-2410Genome polyprotein 1
ChainPRO_0000040547329-3946 kDa protein 1
ChainPRO_0000040548395-1053Cytoplasmic inclusion protein
ChainPRO_00000405491054-11756 kDa protein 2
ChainPRO_00000405501176-1338Viral genome-linked protein
Modified residue1234O-(5'-phospho-RNA)-tyrosine
ChainPRO_00000405511339-1586Nuclear inclusion protein A
ChainPRO_00000405521587-2113Nuclear inclusion protein B
ChainPRO_00000405532114-2410Coat protein

Post-translational modification

Viral genome-linked protein

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).

Genome polyprotein 1

The viral RNA1 of bymoviruses is expressed as a single polyprotein which undergoes post-translational proteolytic processing by the main proteinase NIa-pro resulting in the production of at least eight individual proteins.

Keywords

Structure

3D structure databases

Family & Domains

Features

Showing features for region, domain.

TypeIDPosition(s)Description
Region1-22Disordered
Domain474-632Helicase ATP-binding
Domain647-813Helicase C-terminal
Domain1359-1573Peptidase C4
Domain1857-1980RdRp catalytic
Region2173-2200Disordered

Sequence similarities

Belongs to the bymoviruses polyprotein 1 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,410
  • Mass (Da)
    270,770
  • Last updated
    1994-02-01 v1
  • Checksum
    6CFCF5D7045044B5
MEQTLAQAVSRKSKTDTPMAEERKHFSPMNFSANFVAPELFYSANVRKIKNIFRERSTTRFLDAISSDFELVAFLTLSPAHLMQLETVLRHEMRSCVVPIVTSDASFETVAVIKTALDGMRFHFGYTTLEKGWISMMRHAESCLQESSSSAVNDLQTQIKRVGSLLLSGKNRVEGCELSVLNLTARRFRIEYGLNGTYFGEHVAMLRGLKRYIYGTVPKEFLWAKTKKHSLFTIPAWIKRTPIDCFLFCLRVIPILHRCGVAVSLIYWSCAAALNFPAFMSFLFKRQFAKYLAHSFAKHSIYFMFLTIVAILWSFRTFTSQKPKIVLQARSTAEKEKKLMMILASVVGITYLFDYDIAEALGNCLHKISRLSSYLLDDHQGIASRMFGASYGLQAGDSAEDAVTTIISDLLSVTFKIVDEDASQGTVEDASETTFHSWVGVNTLAGRNMSRPLQYSVNETYALTPQNVQLQARKMADANNCWSMVVGHTGSGKSTYLPVQYSNYLSTKSDRRQQILICEPTQAATENVCAGVAANLGRAVYGRHEGWSRMGDHCIQVMTYGSALQCHAMDPSFISTFDAIFLDEAHDVKEHSLVFESICDTFKSVRKFYVSATPRDGSVCPEAARKYPLHVETSVCDSYRKFIAAQGGGDLLDISKHDTALVFLAGRPECIKAANAWNASVTGEKRAFSLSSDNFATDFSMLTERLKTHKTIIFTTNIIETGVTLSVDCVVDFGHTMRPCLDLNQKALRLDRRRVTRNERQQRIGRAGRLKDGYAIVCGDVDRAVNVISPDVLYGAALLSFKHNVPFYMNETFESSWLEGITKAQADTMTIFKLPIFLTRDLINADGSVAKEFLDVLKKHQFTTSDIKQAPSVTAKHIFPTWASYFSLHQALHYGDDKDEVPHELRYARVPFSVTTLSKFDWPALALACEKHRASMSNVFAGIEEPARVVTLQTNPANIQASITHLTHMSKNYKTLIENNQHVRQSMVTNVMYKWFSSTRITKDLDRNLRRCTDNLAVVEATLSSLRQILAGNTQVHATPHMQSTLEDIIGLQASDTLTEESLASALGIFVPKSNLFLLLATKGFKLVYVVCILLLVNLVYLGLRKWREHLKQKGSNEILTNTMPVSEGGEILAEVMKMEPKMRKNIKKDMDAAVESKLCGFTFVFPDDDKIGLEGKGNKYRPREDARLMYSTREDATLDAWNEKAKERRKKVTDKSEPELRRAYEKRPYFNFYDLQTDSNILEAIFYTTEGDEFFRTADPNKDMNLVADKLRSFLDTKLVVGHHQRQMLEETAKVVIKDTKGTAHHMDISQHDPDHLKQNGSGKIGYPEHRGQFRQEGPAKTADYDLGVEFGTDTDDITLEASTGILLSQVGVDVATRVGRIFIGTFNMNCYFYSDWILVPGHLQDRSGNVTIQFPDQTVQTTTDALNANGVKRFYGLDVIAIRRPAILRPRTKLVKAFAIEEPVIAQMVFVDAQGVRKFTQSVRARKEENSGRWSHKISTVLGMCGCQFWTLERQIDGIHVATNYTKKRNEFQPFTQEVVDFINGPGTKIPYCPWVFDRPACGYASHTALFEKPTTLTDIIHMQASDGLHNINNAIEGFGSSLRGQLVSPPTESTRQRFDKLFGSGSFELIGQMNKGLIDKHVIVGENDDVHDFMREHPTFTWLKDFMNEYAPSVLSYSAYYKDLCKYNRAKHVLTYNPEELHYATKGLIKMLEDAGLTQGSVRTPQQVISDIQWNTSAGPSYQGKKRDLCAHLSDDEVLHLAEVCRQQFLEGKSTGVWNGSLKAELRTIEKVEAEKTRVFTASPITSLFAMKFYVDDFNKKFYATNLKAPHTVGINKFGRGWEKLHDKLNRPGWLHGSGDGSRFDSSIDPLFFDVVKTIRKHFLPSEHHKAIDLIYDEILNTTICLANGMVIKKNVGTQRQPSTVVDNTLVLMTAFLYAYIHKTGDRELALLNERFIFVCNGDDNKFAISPQFDEEFGHDFSPELVELGLTYEFDDITSDICENPYMSLTMVKTPFGVGFSLPVERIIAIMQWSKKGGVLHSYLAGISAIYESFNTPKLFKSIYAYLLWLTEEHEAEILAAMTQSSTALPIPSMLDVYRLHYGDDEIWLQAADPLTDAQKEDARIAAADGARFELADADRRRKVEADRVEAARVKKAADAALKPVNLTATRTPTEDDGKLKTPSGARIPSSAADGNWSVPATKQVNAGLTLKIPLNKLKSVPKSVMEHNNSVALESELKAWTDAVRTSLGITTDEAWIDALIPFIGWCCNNGTSDKHAENQVMQIDSGKGAVTEMSLSPFIVHARMNGGLRRIMRNYSDETVLLITNNKLVAHWSMKHGASANAKYAFDFFVPRSWMNPQDIEVSKQARLAALGTGTYNTMLTSDTTNLRKTTNHRVLDSDGHPELT

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
D01091
EMBL· GenBank· DDBJ
BAA00875.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

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