Q00946 · VPRT_ASFB7

Function

function

Cysteine protease that plays several role during infection including processing of the structural polyprotein or inhibition of the host immune response. Catalyzes the maturation of the pp220 and pp62 polyprotein precursors into core-shell proteins (PubMed:12438573).
Plays a role in the disruption of host pyroptosis via specific cleavage of gasdermin D/GSDMD (PubMed:34890644).
In addition, strongly decreases the host cGAS-STING signaling by targeting IKBKE via its enzymatic activity (PubMed:35437104).
Impairs also host FOXJ1-mediated antiviral effect via degradation of FOXJ1 (PubMed:35513267).
Cleaves host G3BP1 inducing loss of stress granules formation (PubMed:37209818).
Interacts with and induces the degradation of host STAT2 via polyubiquitination of the latter (PubMed:36856422).

Features

Showing features for active site, binding site.

127320406080100120140160180200220240260
TypeIDPosition(s)Description
Active site168
Active site187
Binding site226substrate
Active site232Nucleophile

GO annotations

AspectTerm
Cellular Componenthost cell cytoplasm
Cellular Componentvirion component
Molecular Functioncysteine-type endopeptidase activity
Biological Processproteolysis
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processviral protein processing
Biological Processvirus-mediated perturbation of host defense response

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cysteine protease S273R
  • EC number
  • Short names
    pS273R

Gene names

    • ORF names
      S273R
    • Ordered locus names
      Ba71V-111

Organism names

Accessions

  • Primary accession
    Q00946

Proteomes

Subcellular Location

Host cytoplasm
Virion
Note: Found in the perinuclear cytoplasmic viral factories during assembly.

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis168Loss of activity.
Mutagenesis232Loss of activity.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001017381-273Cysteine protease S273R

Expression

Induction

Expressed in the late phase of the viral replicative cycle.

Keywords

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the peptidase C63 family.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    273
  • Mass (Da)
    31,550
  • Last updated
    1993-04-01 v1
  • Checksum
    C5AA778179C57C17
MSILEKITSSPSECAEHLTNKDSCLSKKIQKELTSFLEKKETLGCDSESCVITHPAVKAYAQQKGLDLSKELETRFKAPGPRNNTGLLTNFNIDETLQRWAIKYTKFFNCPFSMMDFERVHYKFNQVDMVKVYKGEELQYVEGKVVKRPCNTFGCVLNTDFSTGTGKHWVAIFVDMRGDCWSIEYFNSAGNSPPGPVIRWMERVKQQLLKIHHTVKTLAVTNIRHQRSQTECGPYSLFYIRARLDNVSYAHFISARITDEDMYKFRTHLFRIA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M88699
EMBL· GenBank· DDBJ
AAA42734.1
EMBL· GenBank· DDBJ
Genomic DNA
U18466
EMBL· GenBank· DDBJ
AAA65340.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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