Q00771 · KCC1A_EMENI

Function

function

Calcium/calmodulin-dependent protein kinase (PubMed:2835766).
Required in nuclear division cycle for progression from G2 to mitosis. Required for hyphal growth (PubMed:8898358).

Catalytic activity

Activity regulation

Activated by Ca2+/calmodulin (PubMed:8898358).
Binding of calmodulin may relieve intrasteric autoinhibition (Probable)

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site29-37ATP (UniProtKB | ChEBI)
Binding site50ATP (UniProtKB | ChEBI)
Active site142Proton acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functioncalmodulin binding
Molecular Functioncalmodulin-dependent protein kinase activity
Molecular Functionprotein serine kinase activity
Biological Processcell division
Biological Processcellular response to oxidative stress
Biological ProcessG2/M transition of mitotic cell cycle
Biological Processprotein phosphorylation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Calcium/calmodulin-dependent protein kinase cmkA
  • EC number
  • Short names
    CMPK
  • Alternative names
    • Multifunctional calcium/calmodulin-dependent protein kinase
      (ACMPK
      ; CaMK
      )

Gene names

    • Name
      cmkA
    • ORF names
      AN2412

Organism names

Accessions

  • Primary accession
    Q00771
  • Secondary accessions
    • C8VNX3
    • Q5BAL8

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Disruption phenotype

Spores arrest with a single nucleus and fail to extend a germ tube.

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis50Loss of kinase activity.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000860871-414Calcium/calmodulin-dependent protein kinase cmkA

Post-translational modification

Autophosphorylated in a calcium/calmodulin-dependent manner.

Keywords

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain23-278Protein kinase
Region278-314Autoinhibitory domain
Region293-315Calmodulin-binding
Region320-375Disordered
Compositional bias335-371Polar residues
Region394-414Disordered

Domain

The autoinhibitory domain overlaps with the calmodulin binding region and interacts in the inactive folded state with the catalytic domain as a pseudosubstrate.

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    414
  • Mass (Da)
    46,804
  • Last updated
    2009-05-26 v2
  • Checksum
    1E8D58A1C0B2E85C
MSFANMFNKLSGQPESYEKKSLYRFGRTLGAGTYGIVREADCSSGKVAVKIILKRNVRGNERMVYDELDLLQKLNHPHIVHFVDWFESKDKFYIVTQLATGGELFDRICEYGKFTEKDASQTIRQVLDAVNYLHQRNIVHRDLKPENLLYLTRDLDSQLVLADFGIAKMLDNPAEVLTSMAGSFGYAAPEVMLKQGHGKAVDIWSLGVITYTLLCGYSPFRSENLTDLIEECRSGRVVFHERYWKDVSKDAKDFILSLLQVDPAQRPTSEEALKHPWLKGESASDRDLLPEIRAYIARSRLKRGIEIIKLANRIEALKMQEEDEEDIPSAVDVQASEASDKSGLSPFPALSTENSNTHPASTGNGESGGTKKRSLSKIARGAIFREVVLAKVREMKENEEREKVEREARERAHS

Sequence caution

The sequence EAA64523.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, sequence conflict.

TypeIDPosition(s)Description
Compositional bias335-371Polar residues
Sequence conflict408in Ref. 1; AAB97502 and 2; AAD22581

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
M74120
EMBL· GenBank· DDBJ
AAB97502.1
EMBL· GenBank· DDBJ
mRNA
AF054580
EMBL· GenBank· DDBJ
AAD22581.1
EMBL· GenBank· DDBJ
Genomic DNA
AACD01000039
EMBL· GenBank· DDBJ
EAA64523.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
BN001307
EMBL· GenBank· DDBJ
CBF86796.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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