P9WPQ4 · BIOD_MYCTO

Function

function

Catalyzes a mechanistically unusual reaction, the ATP-dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA, also called 7,8-diammoniononanoate) to form a ureido ring.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Cofactor biosynthesis; biotin biosynthesis; biotin from 7,8-diaminononanoate: step 1/2.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site12-17ATP (UniProtKB | ChEBI)
Binding site16Mg2+ (UniProtKB | ChEBI)
Active site37
Binding site41substrate
Binding site49ATP (UniProtKB | ChEBI)
Binding site49Mg2+ (UniProtKB | ChEBI)
Binding site108Mg2+ (UniProtKB | ChEBI)
Binding site108-111ATP (UniProtKB | ChEBI)
Binding site169-170ATP (UniProtKB | ChEBI)
Binding site197-199ATP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functiondethiobiotin synthase activity
Molecular Functionmagnesium ion binding
Biological Processbiotin biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ATP-dependent dethiobiotin synthetase BioD
  • EC number
  • Alternative names
    • DTB synthetase
      (DTBS
      )
    • Dethiobiotin synthase

Gene names

    • Name
      bioD
    • Ordered locus names
      MT1621

Organism names

Accessions

  • Primary accession
    P9WPQ4
  • Secondary accessions
    • L0T9U0
    • O06620

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004269111-226ATP-dependent dethiobiotin synthetase BioD

Interaction

Subunit

Homodimer.

Structure

Family & Domains

Sequence similarities

Belongs to the dethiobiotin synthetase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    226
  • Mass (Da)
    22,426
  • Last updated
    2014-04-16 v1
  • Checksum
    43581D116CB02AAE
MTILVVTGTGTGVGKTVVCAALASAARQAGIDVAVCKPVQTGTARGDDDLAEVGRLAGVTQLAGLARYPQPMAPAAAAEHAGMALPARDQIVRLIADLDRPGRLTLVEGAGGLLVELAEPGVTLRDVAVDVAAAALVVVTADLGTLNHTKLTLEALAAQQVSCAGLVIGSWPDPPGLVAASNRSALARIATVRAALPAGAASLDAGDFAAMSAAAFDRNWVAGLVG

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE000516
EMBL· GenBank· DDBJ
AAK45888.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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