P9WPJ7 · MTCA1_MYCTU
- ProteinBeta-carbonic anhydrase 1
- GenemtcA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids163 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.
Miscellaneous
Was identified as a high-confidence drug target.
Catalytic activity
- H+ + hydrogencarbonate = CO2 + H2O
Cofactor
Note: Binds 1 zinc ion per subunit.
Activity regulation
Inhibited by sulfonamides and sulfamates. The best inhibitors are 3-bromosulfanilamide and indisulam.
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | carbonate dehydratase activity | |
Molecular Function | zinc ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameBeta-carbonic anhydrase 1
- EC number
- Short namesBeta-CA 1
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis complex
Accessions
- Primary accessionP9WPJ7
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Chemistry
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Initiator methionine | 1 | Removed | ||||
Sequence: M | ||||||
Modified residue | 2 | N-acetylthreonine | ||||
Sequence: T | ||||||
Chain | PRO_0000103784 | 2-163 | Beta-carbonic anhydrase 1 | |||
Sequence: TVTDDYLANNVDYASGFKGPLPMPPSKHIAIVACMDARLDVYRMLGIKEGEAHVIRNAGCVVTDDVIRSLAISQRLLGTREIILLHHTDCGMLTFTDDDFKRAIQDETGIRPTWSPESYPDAVEDVRQSLRRIEVNPFVTKHTSLRGFVFDVATGKLNEVTP |
Keywords
- PTM
Proteomic databases
PTM databases
Structure
Sequence
- Sequence statusComplete
- Length163
- Mass (Da)18,189
- Last updated2014-04-16 v1
- ChecksumDDD342B7DBFE5AA0
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL123456 EMBL· GenBank· DDBJ | CCP44040.1 EMBL· GenBank· DDBJ | Genomic DNA |