P9WP41 · CULP2_MYCTU
- ProteinProbable carboxylesterase Culp2
- Genecut2
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids230 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Shows weak esterase activity with the p-nitrophenol-linked aliphatic ester pNP-butyrate. Does not exhibit cutinase activity.
Induces interferon-gamma (IFN-gamma) release in animal models and in human TB patients (PubMed:10076913, PubMed:9673225).
Also induces a strong delayed-type hypersensitivity (DTH) response in animal models (PubMed:9673225).
Also induces a strong delayed-type hypersensitivity (DTH) response in animal models (PubMed:9673225).
Biotechnology
Five Rv2301 high activity binding peptides (HABPs) could be included as components of an antituberculosis vaccine.
Features
Showing features for active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 123 | Nucleophile | |||
Active site | 189 | ||||
Active site | 207 | Proton donor/acceptor | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular region | |
Molecular Function | carboxylic ester hydrolase activity | |
Biological Process | evasion of host immune response |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProbable carboxylesterase Culp2
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis complex
Accessions
- Primary accessionP9WP41
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
PTM/Processing
Features
Showing features for signal, chain, disulfide bond.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-43 | ||||
Chain | PRO_0000006449 | 44-230 | Probable carboxylesterase Culp2 | ||
Disulfide bond | 45↔112 | ||||
Disulfide bond | 185↔192 | ||||
Keywords
- PTM
Proteomic databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length230
- Mass (Da)23,926
- Last updated2014-04-16 v1
- Checksum3707CA5016AEE5A3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL123456 EMBL· GenBank· DDBJ | CCP45083.1 EMBL· GenBank· DDBJ | Genomic DNA |