P9WP41 · CULP2_MYCTU

Function

function

Shows weak esterase activity with the p-nitrophenol-linked aliphatic ester pNP-butyrate. Does not exhibit cutinase activity.
Induces interferon-gamma (IFN-gamma) release in animal models and in human TB patients (PubMed:10076913, PubMed:9673225).
Also induces a strong delayed-type hypersensitivity (DTH) response in animal models (PubMed:9673225).

Biotechnology

Five Rv2301 high activity binding peptides (HABPs) could be included as components of an antituberculosis vaccine.

Features

Showing features for active site.

123020406080100120140160180200220
TypeIDPosition(s)Description
Active site123Nucleophile
Active site189
Active site207Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Molecular Functioncarboxylic ester hydrolase activity
Biological Processevasion of host immune response

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Probable carboxylesterase Culp2
  • EC number
  • Alternative names
    • CFP25
    • Cutinase-like protein 2
      (Culp2
      )

Gene names

    • Name
      cut2
    • ORF names
      MTCY339.08c
    • Ordered locus names
      Rv2301

Organism names

Accessions

  • Primary accession
    P9WP41
  • Secondary accessions
    • L0TAS9
    • P63881
    • Q50664

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, disulfide bond.

Type
IDPosition(s)Description
Signal1-43
ChainPRO_000000644944-230Probable carboxylesterase Culp2
Disulfide bond45↔112
Disulfide bond185↔192

Keywords

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the cutinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    230
  • Mass (Da)
    23,926
  • Last updated
    2014-04-16 v1
  • Checksum
    3707CA5016AEE5A3
MNDLLTRRLLTMGAAAAMLAAVLLLTPITVPAGYPGAVAPATAACPDAEVVFARGRFEPPGIGTVGNAFVSALRSKVNKNVGVYAVKYPADNQIDVGANDMSAHIQSMANSCPNTRLVPGGYSLGAAVTDVVLAVPTQMWGFTNPLPPGSDEHIAAVALFGNGSQWVGPITNFSPAYNDRTIELCHGDDPVCHPADPNTWEANWPQHLAGAYVSSGMVNQAADFVAGKLQ

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL123456
EMBL· GenBank· DDBJ
CCP45083.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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