P9WNS5 · DUT_MYCTU

Function

function

This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.

Miscellaneous

Each trimer binds three substrate molecules. The ligands are bound between subunits, and for each substrate molecule, residues from adjacent subunits contribute to the binding interactions.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Pathway

Pyrimidine metabolism; dUMP biosynthesis; dUMP from dCTP (dUTP route): step 2/2.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site64-66substrate
Binding site77substrate
Binding site81-83substrate
Binding site91substrate

GO annotations

AspectTerm
Molecular FunctiondUTP diphosphatase activity
Molecular Functionmagnesium ion binding
Biological ProcessdUMP biosynthetic process
Biological ProcessdUTP catabolic process
Biological ProcessdUTP metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Deoxyuridine 5'-triphosphate nucleotidohydrolase
  • EC number
  • Short names
    dUTPase
  • Alternative names
    • dUTP pyrophosphatase

Gene names

    • Name
      dut
    • ORF names
      MTCY05A6.18c
    • Ordered locus names
      Rv2697c

Organism names

Accessions

  • Primary accession
    P9WNS5
  • Secondary accessions
    • L0TAD4
    • O07199
    • P0A552

Proteomes

Organism-specific databases

Phenotypes & Variants

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001828841-154Deoxyuridine 5'-triphosphate nucleotidohydrolase

Proteomic databases

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the dUTPase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    154
  • Mass (Da)
    15,803
  • Last updated
    2014-04-16 v1
  • Checksum
    836D5E6420EF455B
MSTTLAIVRLDPGLPLPSRAHDGDAGVDLYSAEDVELAPGRRALVRTGVAVAVPFGMVGLVHPRSGLATRVGLSIVNSPGTIDAGYRGEIKVALINLDPAAPIVVHRGDRIAQLLVQRVELVELVEVSSFDEAGLASTSRGDGGHGSSGGHASL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL123456
EMBL· GenBank· DDBJ
CCP45495.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp