P9WLP7 · MBCA_MYCTU

Function

function

Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:30315706, PubMed:30792174).
Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site (PubMed:30792174).

Biotechnology

Molecules that disrupt the MbcT-MbcA complex could be candidates for anti-tuberculosis therapy.

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Mycobacterial cidal antitoxin MbcA
  • Alternative names
    • Antitoxin Xre
    • ucAT8 antitoxin

Gene names

    • Name
      mbcA
    • ORF names
      MTCY39.29
    • Ordered locus names
      Rv1990c

Organism names

Accessions

  • Primary accession
    P9WLP7
  • Secondary accessions
    • L0TB09
    • P64909
    • Q10868

Proteomes

Organism-specific databases

Phenotypes & Variants

Disruption phenotype

Essential, it cannot be deleted (PubMed:28096490).
Deletion of the mbcT-mbcA operon has no visible phenotype (PubMed:30792174).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis104-113No longer neutralizes the toxic effect of MbcT.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000141161-113Mycobacterial cidal antitoxin MbcA

Proteomic databases

Expression

Induction

Induced by hypoxia (PubMed:18231589).
Expression probably induced in both active and resting C57BL/6 mouse macrophages (PubMed:20628579).
Induced in persister cells (PubMed:21673191).
Induced by Ethambutol, Isoniazid and streptomycin treatment and by starvation, repressed by rifampicin treatment (PubMed:28724903).
Probably part of the mbcT-mbcA operon (PubMed:30792174).

Interaction

Subunit

Heterotetramer with 2 subunits each of MbcT and MbcA; the tetramers further assemble into trimers with 3-fold symmetry.

Protein-protein interaction databases

Family & Domains

Sequence similarities

Belongs to the MbcA/ParS/Xre antitoxin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    113
  • Mass (Da)
    12,488
  • Last updated
    2014-04-16 v1
  • Checksum
    41978D1BE45E74C9
MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPNRLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL123456
EMBL· GenBank· DDBJ
CCP44760.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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