P9WLP7 · MBCA_MYCTU
- ProteinMycobacterial cidal antitoxin MbcA
- GenembcA
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids113 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Antitoxin component of a type II toxin-antitoxin (TA) system (PubMed:30315706, PubMed:30792174).
Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site (PubMed:30792174).
Neutralizes the activity of cognate toxin MbcT by blocking access to the toxin active site (PubMed:30792174).
Biotechnology
Molecules that disrupt the MbcT-MbcA complex could be candidates for anti-tuberculosis therapy.
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended nameMycobacterial cidal antitoxin MbcA
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis complex
Accessions
- Primary accessionP9WLP7
- Secondary accessions
Proteomes
Organism-specific databases
Phenotypes & Variants
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000014116 | 1-113 | Mycobacterial cidal antitoxin MbcA | |||
Sequence: MGVNVLASTVSGAIERLGLTYEEVGDIVDASPRSVARWTAGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPNRLLEHRKPADLVRDGEYQRVLALIDAMAEGVFV |
Proteomic databases
Expression
Induction
Induced by hypoxia (PubMed:18231589).
Expression probably induced in both active and resting C57BL/6 mouse macrophages (PubMed:20628579).
Induced in persister cells (PubMed:21673191).
Induced by Ethambutol, Isoniazid and streptomycin treatment and by starvation, repressed by rifampicin treatment (PubMed:28724903).
Probably part of the mbcT-mbcA operon (PubMed:30792174).
Expression probably induced in both active and resting C57BL/6 mouse macrophages (PubMed:20628579).
Induced in persister cells (PubMed:21673191).
Induced by Ethambutol, Isoniazid and streptomycin treatment and by starvation, repressed by rifampicin treatment (PubMed:28724903).
Probably part of the mbcT-mbcA operon (PubMed:30792174).
Interaction
Subunit
Heterotetramer with 2 subunits each of MbcT and MbcA; the tetramers further assemble into trimers with 3-fold symmetry.
Protein-protein interaction databases
Structure
Family & Domains
Sequence similarities
Belongs to the MbcA/ParS/Xre antitoxin family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length113
- Mass (Da)12,488
- Last updated2014-04-16 v1
- Checksum41978D1BE45E74C9
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL123456 EMBL· GenBank· DDBJ | CCP44760.1 EMBL· GenBank· DDBJ | Genomic DNA |