P9WL00 · HGLS_MYCTO
- Protein2-oxoadipate dioxygenase/decarboxylase
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids415 (go to sequence)
- Protein existenceInferred from homology
- Annotation score2/5
Function
function
Catalyzes the decarboxylation and hydroxylation of 2-oxoadipate (2OA) to form D-2-hydroxyglutarate (D-2-HGA).
Catalytic activity
- 2-oxoadipate + O2 = (R)-2-hydroxyglutarate + CO2
Cofactor
Features
Showing features for binding site, site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 66 | 2-oxoadipate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 66 | Fe2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 70 | 2-oxoadipate (UniProtKB | ChEBI) | ||||
Sequence: R | ||||||
Site | 70 | Important for substrate specificity | ||||
Sequence: R | ||||||
Binding site | 225 | 2-oxoadipate (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 225 | Fe2+ (UniProtKB | ChEBI) | ||||
Sequence: H | ||||||
Binding site | 296 | Fe2+ (UniProtKB | ChEBI) | ||||
Sequence: E | ||||||
Binding site | 361 | 2-oxoadipate (UniProtKB | ChEBI) | ||||
Sequence: A |
GO annotations
Aspect | Term | |
---|---|---|
Molecular Function | dioxygenase activity | |
Molecular Function | metal ion binding |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended name2-oxoadipate dioxygenase/decarboxylase
- EC number
- Alternative names
Gene names
Organism names
- Strain
- Taxonomic lineageBacteria > Actinomycetota > Actinomycetes > Mycobacteriales > Mycobacteriaceae > Mycobacterium > Mycobacterium tuberculosis complex
Accessions
- Primary accessionP9WL00
- Secondary accessions
Proteomes
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000427565 | 1-415 | 2-oxoadipate dioxygenase/decarboxylase | |||
Sequence: MSRSKRLQTGQLRARFAAGLSAMYAAEVPAYGTLVEVCAQVNSDYLTRHRRAERLGSLQRVTAERHGAIRVGNPAELAAVADLFAAFGMLPVGYYDLRTAESPIPVVSTAFRPIDANELAHNPFRVFTSMLAIEDRRYFDADLRTRVQTFLARRQLFDPALLAQARAIAADGGCDADDAPAFVAAAVAAFALSREPVEKSWYDELSRVSAVAADIAGVGSTHINHLTPRVLDIDDLYRRMTERGITMIDTIQGPPRTDGPDVLLRQTSFRALAEPRMFRDEDGTVTPGILRVRFGEVEARGVALTPRGRERYEAAMAAADPAAVWATHFPSTDAEMAAQGLAYYRGGDPSAPIVYEDFLPASAAGIFRSNLDRDSQTGDGPDDAGYNVDWLAGAIGRHIHDPYALYDALAQEERR |
Structure
Sequence
- Sequence statusComplete
- Length415
- Mass (Da)45,332
- Last updated2014-04-16 v1
- Checksum0D9612154C265130
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE000516 EMBL· GenBank· DDBJ | AAK47734.1 EMBL· GenBank· DDBJ | Genomic DNA |