P9WGD5 · SSB_MYCTU

Function

function

Binds single-stranded (ss)DNA (PubMed:10491108, PubMed:20724443, PubMed:24387047).
At low concentrations (0.02 to 0.16 uM), stimulates the 5'-3' helicase activity of DnaB (PubMed:24387047).
At higher concentrtions eventually totally inhibits DnaB helicase (PubMed:24387047).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular region
Cellular Componentnucleoid
Cellular Componentplasma membrane
Molecular Functionsingle-stranded DNA binding
Biological ProcessDNA damage response
Biological ProcessDNA replication
Biological Processresponse to antibiotic

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Single-stranded DNA-binding protein
  • Short names
    SSB

Gene names

    • Name
      ssb
    • ORF names
      MTCY21D4.17
    • Ordered locus names
      Rv0054

Organism names

Accessions

  • Primary accession
    P9WGD5
  • Secondary accessions
    • L0T5J5
    • P0A610
    • P71711

Proteomes

Organism-specific databases

Subcellular Location

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis122-fold increase of stimulation of DnaB helicase activity; when associated with L-132.
Mutagenesis21No longer stimulates DnaB helicase activity.
Mutagenesis1322-fold increase of stimulation of DnaB helicase activity; when associated with S-12.
Mutagenesis145-164Loss of interaction with DnaB, weakly stimulates helicase activity of DnaB.
Mutagenesis155-164Still interacts with DnaB.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000960691-164Single-stranded DNA-binding protein

Proteomic databases

Interaction

Subunit

Homotetramer (PubMed:10491108, PubMed:12888346).
Interacts with DnaB (PubMed:24387047).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY P9WGD5dnaB P9WMR33EBI-9081374, EBI-9081402

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain1-110SSB
Region120-164Disordered
Compositional bias121-145Polar residues

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    164
  • Mass (Da)
    17,353
  • Last updated
    2014-04-16 v1
  • Checksum
    14797F8379FC2036
MAGDTTITIVGNLTADPELRFTPSGAAVANFTVASTPRIYDRQTGEWKDGEALFLRCNIWREAAENVAESLTRGARVIVSGRLKQRSFETREGEKRTVIEVEVDEIGPSLRYATAKVNKASRSGGFGSGSRPAPAQTSSASGDDPWGSAPASGSFGGGDDEPPF

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias121-145Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL123456
EMBL· GenBank· DDBJ
CCP42776.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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