P9WG77 · THID_MYCTU

Function

function

Catalyzes the phosphorylation of hydroxymethylpyrimidine phosphate (HMP-P) to HMP-PP, and of HMP to HMP-P.

Miscellaneous

Was identified as a high-confidence drug target.

Catalytic activity

Pathway

Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 2/3.
Cofactor biosynthesis; thiamine diphosphate biosynthesis; 4-amino-2-methyl-5-diphosphomethylpyrimidine from 5-amino-1-(5-phospho-D-ribosyl)imidazole: step 3/3.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site544-amino-5-hydroxymethyl-2-methylpyrimidine (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular FunctionATP binding
Molecular Functionhydroxymethylpyrimidine kinase activity
Molecular Functionphosphomethylpyrimidine kinase activity
Biological Processphosphorylation
Biological Processthiamine biosynthetic process
Biological Processthiamine diphosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase
  • EC number
  • Alternative names
    • Hydroxymethylpyrimidine kinase (HMP kinase)
    • Hydroxymethylpyrimidine phosphate kinase (HMP-P kinase; HMP-phosphate kinase; HMPP kinase)

Gene names

    • Name
      thiD
    • ORF names
      MTCY22G10.19c
    • Ordered locus names
      Rv0422c

Organism names

Accessions

  • Primary accession
    P9WG77
  • Secondary accessions
    • L0T6F0
    • P66913
    • P96268

Proteomes

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for initiator methionine, chain.

TypeIDPosition(s)Description
Initiator methionine1Removed
ChainPRO_00001920232-275Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase

Proteomic databases

Interaction

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Sequence similarities

Belongs to the ThiD family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    275
  • Mass (Da)
    28,565
  • Last updated
    2022-05-25 v2
  • Checksum
    1B084A59FF394425
MNYLPLAPPGMTPPRVLSIAGSDSGGGAGIQADMRTMALLGVHACVAVTAVTVQNTLGVKDIHEVPNDVVAGQIEAVVTDIGVQAAKTGMLASSRIVATVAATWRRLELSVPLVVDPVCASMHGDPLLAPSALDSLRGQLFPLATLLTPNLDEARLLVDIEVVDAESQRAAAKALHALGPQWVLVKGGHLRSSDGSCDLLYDGVSCYQFDAQRLPTGDDHGGGDTLATAIAAALAHGFTVPDAVDFGKRWVTECLRAAYPLGRGHGPVSPLFRLS

Sequence caution

The sequence CCP43153.1 differs from that shown. Reason: Erroneous initiation Truncated N-terminus.

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AL123456
EMBL· GenBank· DDBJ
CCP43153.1
EMBL· GenBank· DDBJ
Genomic DNA Different initiation

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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