P9WEW5 · PCH18_PENRB

  • Protein
    Subtilisin-like serine protease Pen ch 18
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Serine protease.

Features

Showing features for active site, site.

149450100150200250300350400450
Type
IDPosition(s)Description
Active site182Charge relay system
Active site214Charge relay system
Site311Important for catalytic activity
Active site376Charge relay system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular FunctionIgE binding
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Subtilisin-like serine protease Pen ch 18
  • EC number
  • Alternative names
    • Vacuolar serine protease
  • Allergen name
    Pen ch 18

Organism names

  • Taxonomic identifier
  • Strain
    • ATCC 9179 / BCRC 30568 / CBS 197.46 / NRRL 832 / QM 940
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium > Penicillium chrysogenum species complex

Accessions

  • Primary accession
    P9WEW5
  • Secondary accessions
    • Q9HF04

Subcellular Location

Phenotypes & Variants

Allergenic properties

Causes an allergic reaction in human. Binds to IgE of patients with bronchial asthma (PubMed:10231324, PubMed:14510716, PubMed:18760997).
Binds to IgE in 24% of the 41 patients tested (PubMed:14510716).

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis225Significantly reduced IgE-binding.
Mutagenesis226Significantly reduced IgE-binding.
Mutagenesis227Significantly reduced IgE-binding.

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, chain, glycosylation.

Type
IDPosition(s)Description
Signal1-16
PropeptidePRO_000044666817-136Removed in mature form
ChainPRO_5004327177137-453Subtilisin-like serine protease Pen ch 18
Glycosylation244N-linked (GlcNAc...) asparagine
Glycosylation280N-linked (GlcNAc...) asparagine
Glycosylation443N-linked (GlcNAc...) asparagine
PropeptidePRO_0000446669454-494Removed in mature form

Keywords

Structure

Family & Domains

Features

Showing features for domain, region.

Type
IDPosition(s)Description
Domain43-136Inhibitor I9
Domain146-448Peptidase S8
Region180-198IgE-binding
Region209-231IgE-binding

Sequence similarities

Belongs to the peptidase S8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    494
  • Mass (Da)
    52,309
  • Last updated
    2020-12-02 v1
  • Checksum
    5F6A37AF0DAEA894
MKGFLSLTLLPLLVAASPVAVNSIHNDAAPILSSMTSKDIPDSYIVVFKKHVDPSSASAHQSWLQEVHTAHTGRMELKKRSLFGFDFEAFMGLKHTFHIAGSLLGYAGHFHEDVIEQIRRHPDVDYIEKDSEVRTMSEGSVEKNAPWGLARISHRESLSFGNFNKYLYAEEGGEGVDAYVIDTGANVKHVDFEGRANWGKTIPQGDADEDGNGHGTHCSGTIAGKKFGVAKKANVYAVKVLRSNGSGTMSDVVKGVEWAAEAHIKKSKKGDKKFKGSVANMSLGGGSSRTLDLAVNAAVDAGIHFAVAAGNDNADACNYSPAAAEKAITVGASTLADERAYFSNYGKCTDIFAPGLNILSTWVGSDHATNTISGTSMASPHIAGLLAYYVSLAPAKDSAYAVADVTPKQLKAALISVATEGTLTDIPSDTPNLLAWNGGGSANYTKILADGGYKAHNAETTVEDRIGGIIDSAEKAFHKELGAIYSEIKDAVSA

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF263454
EMBL· GenBank· DDBJ
AAG44693.2
EMBL· GenBank· DDBJ
mRNA

Similar Proteins

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