P9WEW4 · PCH13_PENCH

Function

function

Serine protease that hydrolyzes casein, gelatin and human collagen type IV, but not elastin in vitro (By similarity).
Hydrolyzes OCLN of the human lung epithelial cells at 202-Gln-|-Ser-203 and Gln-211-|-Ile-212 (By similarity).

Activity regulation

Inhibited by phenylmethanesulfonyl fluoride (PMSF) and diethyl pyrocarbonate (DEPC), but not by benzamidine.

Features

Showing features for active site, site.

139850100150200250300350
TypeIDPosition(s)Description
Active site157Charge relay system
Active site188Charge relay system
Site280Important for catalytic activity
Active site343Charge relay system

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentextracellular space
Molecular FunctionIgE binding
Molecular Functionserine-type endopeptidase activity
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Subtilisin-like serine protease EN45_076310
  • EC number
  • Alternative names
    • Alkaline serine protease

Gene names

    • ORF names
      EN45_076310

Organism names

  • Taxonomic identifier
  • Strain
    • P2niaD18
  • Taxonomic lineage
    Eukaryota > Fungi > Dikarya > Ascomycota > Pezizomycotina > Eurotiomycetes > Eurotiomycetidae > Eurotiales > Aspergillaceae > Penicillium > Penicillium chrysogenum species complex

Accessions

  • Primary accession
    P9WEW4
  • Secondary accessions
    • Q8NKG0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for signal, propeptide, glycosylation, chain.

TypeIDPosition(s)Description
Signal1-19
PropeptidePRO_000045134320-115Removed in mature form
Glycosylation113N-linked (GlcNAc...) asparagine
ChainPRO_0000451344116-398Subtilisin-like serine protease EN45_076310
Glycosylation249N-linked (GlcNAc...) asparagine

Keywords

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain35-113Inhibitor I9
Region124-134IgE-binding
Domain125-398Peptidase S8
Region163-170IgE-binding
Region175-195Disordered
Compositional bias176-195Polar residues
Region227-245IgE-binding
Region310-318IgE-binding

Sequence similarities

Belongs to the peptidase S8 family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    398
  • Mass (Da)
    40,362
  • Last updated
    2020-12-02 v1
  • Checksum
    8E85FE9E942080D3
MGFLKLLSTSLATLAVVNAGKLLTANDGDEVVPSSYIVVMNDGVSTAQFETHRNWAANVHARTRSLKGGESGPGKHFDINGMKGYSASFDDRTVKDIASDPTVKYVEPDMVVNATANVVQRNAPSWGLSRISSKKSGATDYVYDSTAGEGIVIYGVDTGIDIGHADFGGRAEWGTNTADNDDTDGNGHGTHTASTAAGSKFGVAKKASVVAVKVLGADGSGTNSQVIAGMDWAVKDSKSRGATGKSVMNMSLGGAYSRAMNDAAANVVRSGVFLSVAAGNEAQDASNSSPASAPNVCTIAASTNSDGSASFTNFGSVVDLYAPGKDITAAYPGGGSKTLSGTSMAAPHVAGAAAYLMALEGVTSDKACARIVELAISSISSAPSGTTSKLLYNGINAQ

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias176-195Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CM002799
EMBL· GenBank· DDBJ
KZN89038.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

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