P9WEU0 · ILID_HYPJQ

Function

function

S-adenosyl-l-methionine-dependent Diels-Alderase; part of the gene cluster that mediates the biosynthesis of ilicicolin H, a 4-hydroxy-2-pyridonealkaloid that has potent and broad antifungal activities by inhibiting the mitochondrial respiration chain (PubMed:34947016).
IliD catalyzes the Diels-Alder reaction that converts the acyclic 2-pyridone intermediate to 8-epi-ilicicolin H (PubMed:34947016).
The biosynthesis of ilicicolin H starts with formation of the tetramic acid by the hybrid PKS-NRPS synthetase iliA with the partnering trans-enoyl reductase iliB since iliA lacks a designated enoylreductase (ER) domain. The cytochrome P450 monooxygenase iliC then catalyzes the ring expansion of the tetramate to the acyclic 2-pyridone. The pericyclase iliD further converts the acyclic 2-pyridone into 8-epi-ilicicolin H. 8-epi-ilicicolin H might then spontaneously convert to ilicicolin H since ilicicolin H is produced in the absence of the epimerase iliE, in contrast to what was observed for the Talaromyces variabilis ilicolin H biosynthetic pathway (Probable) (PubMed:34947016).

Catalytic activity

Cofactor

S-adenosyl-L-methionine (UniProtKB | Rhea| CHEBI:59789 )

Pathway

Mycotoxin biosynthesis.

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    S-adenosyl-L-methionine-dependent Diels-Alderase iliD
  • EC number
  • Alternative names
    • C-methyltransferase iliD
    • Ilicicolin H biosynthesis cluster protein D
    • Pericyclase iliD

Gene names

    • Name
      iliD

Organism names

Accessions

  • Primary accession
    P9WEU0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004557141-305S-adenosyl-L-methionine-dependent Diels-Alderase iliD

Structure

3D structure databases

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    305
  • Mass (Da)
    34,700
  • Last updated
    2022-08-03 v1
  • Checksum
    5FB02C2F1DA40120
MSSTQTTAAEPIMTDNVALRAYYESWDSRVVYQIIMGGTQHFGYWDKDTYWPFPLGSKLRRSMEQKLMEILALPKGSRVLDAGCGVGHVARYMAQHGMRVFGIDIIDWAIEDARKAAKDAGLSKEMMSVEKMDYHHLDSLASESFDGVYTMQAFGHAVDPQKAMAGFFRVVRPGGRIAMVEVERKTAAKHDDPNDRLTQELKMVNDYTVMPTNEAASEDYFKNLLEEAGFVDVVVRDWQPNILPILRLFYSLVMIPYLFFRLFGNEKSFINMICARSGYAGRSRWRFVAITATKAGEKLEDHKSK

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
GL985060
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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