P9WEM0 · ASTK_ASPOR

Function

function

Sesquiterpene phosphatase; part of the gene cluster that mediates the biosynthesis of astellolides, drimane-type sesquiterpene esters that show antimicrobial, anti-inflammatory, and anti-tumor activities (PubMed:27628599).
The first step in astellolide biosynthesis is performed by the sesquiterpene cyclase astC that catalyzes the formation of drimanyl pyrophosphate from farnesyl pyrophosphate (PubMed:27628599).
Drimanyl pyrophosphate is then dephosphorylated by the sesquiterpene phosphatase astI to produce drimanyl monophosphate which is further dephosphorylated to drim-8-ene-11-ol by atsK (PubMed:27628599).
Drim-8-ene-11-ol is converted to confertifolin, probably by the cytochrome P450 monooxygenase astD and/or the dehydrogenase astE (PubMed:27628599).
The cytochrome P450 monooxygenases astB, astF and astJ then hydroxylate confertifolin at C6, C14, or C15 to form trihydroxy confertifolin (PubMed:27628599).
The nonribosomal peptide synthetase astA catalyzes ester bond formation between trihydroxy contifolin and benzoic acid (BA) or 4-hydroxy benzoic acid (4HBA), leading to the formation of dideacetyl astellolides A and B, respectively (PubMed:27628599).
Finally, the O-acetyltransferase astG converts dideacetyl astellolides A and B into deacetyl astellolides A and B (PubMed:27628599).

Catalytic activity

Pathway

Secondary metabolite biosynthesis; terpenoid biosynthesis.

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Sesquiterpene phosphatase astK
  • EC number
  • Alternative names
    • Astellolide biosynthesis cluster protein K

Gene names

    • Name
      astK
    • ORF names
      AORIB40_NS.05916

Organism names

Accessions

  • Primary accession
    P9WEM0

Proteomes

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004613921-196Sesquiterpene phosphatase astK

Expression

Induction

Expression is regulated by the secondary metabolite regulator cclA.

Family & Domains

Sequence similarities

Belongs to the HAD-like hydrolase superfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    196
  • Mass (Da)
    21,913
  • Last updated
    2024-11-27 v1
  • Checksum
    1E04E33E04A5BCEB
MCTTFKAAIFDMGGVLFTWNPIVDTQVSLKDLGTIINSETWEQFERGKIEPDDCYHQLGSQIGLPGSEIAATFRQTTGCLRPDARMTSLLRELKGQGVAVYMMTNIPAPDFHQLREMHYEWDLFDGIFASALEGMRKPDLEFYEHVLKQIDTSAAETIFVDDKLENVIAAQAVGMVGLHLTDSLATCMELRQLVGC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
BA000051
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Similar Proteins

Disclaimer

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