P98105 · LYAM2_RAT

Function

function

Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis.

Features

Showing features for binding site.

154950100150200250300350400450500
TypeIDPosition(s)Description
Binding site101Ca2+ (UniProtKB | ChEBI)
Binding site101-109a carbohydrate (UniProtKB | ChEBI)
Binding site103Ca2+ (UniProtKB | ChEBI)
Binding site109Ca2+ (UniProtKB | ChEBI)
Binding site113-118a carbohydrate (UniProtKB | ChEBI)
Binding site126Ca2+ (UniProtKB | ChEBI)
Binding site126-128a carbohydrate (UniProtKB | ChEBI)
Binding site127Ca2+ (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcaveola
Cellular Componentclathrin-coated pit
Cellular Componentcortical cytoskeleton
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Cellular Componentmembrane raft
Cellular Componentperinuclear region of cytoplasm
Cellular Componentplasma membrane
Molecular Functionmetal ion binding
Molecular Functionoligosaccharide binding
Molecular Functionphospholipase binding
Molecular Functionsialic acid binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processactin filament-based process
Biological Processcell adhesion
Biological Processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Biological Processleukocyte cell-cell adhesion
Biological Processleukocyte migration
Biological Processleukocyte tethering or rolling
Biological Processpositive regulation of leukocyte migration
Biological Processpositive regulation of leukocyte tethering or rolling
Biological Processpositive regulation of receptor internalization
Biological Processresponse to cytokine
Biological Processresponse to interleukin-1

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E-selectin
  • Alternative names
    • CD62 antigen-like family member E
    • Endothelial leukocyte adhesion molecule 1 (ELAM-1)
    • Leukocyte-endothelial cell adhesion molecule 2 (LECAM2)
  • CD Antigen Name
    • CD62E

Gene names

    • Name
      Sele
    • Synonyms
      Elam-1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    P98105

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain22-494Extracellular
Transmembrane495-516Helical
Topological domain517-549Cytoplasmic

Keywords

Phenotypes & Variants

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_000001749622-549E-selectin
Glycosylation25N-linked (GlcNAc...) asparagine
Disulfide bond40↔138
Glycosylation60N-linked (GlcNAc...) asparagine
Disulfide bond111↔130
Disulfide bond143↔154
Glycosylation145N-linked (GlcNAc...) asparagine
Disulfide bond148↔163
Disulfide bond165↔174
Disulfide bond180↔225
Glycosylation192N-linked (GlcNAc...) asparagine
Disulfide bond193↔206
Glycosylation203N-linked (GlcNAc...) asparagine
Disulfide bond210↔238
Disulfide bond243↔287
Disulfide bond256↔269
Glycosylation266N-linked (GlcNAc...) asparagine
Disulfide bond273↔300
Disulfide bond305↔350
Glycosylation313N-linked (GlcNAc...) asparagine
Glycosylation320N-linked (GlcNAc...) asparagine
Glycosylation333N-linked (GlcNAc...) asparagine
Disulfide bond336↔363
Disulfide bond368↔413
Disulfide bond399↔426
Disulfide bond431↔472
Glycosylation441N-linked (GlcNAc...) asparagine
Disulfide bond458↔485
Glycosylation465N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with SELPLG/PSGL1 and PODXL2 through the sialyl Lewis X epitope. SELPLG sulfation appears not to be required for this interaction.

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain22-139C-type lectin
Domain140-175EGF-like
Domain178-240Sushi 1
Domain241-302Sushi 2
Domain303-365Sushi 3
Domain366-428Sushi 4
Domain429-487Sushi 5

Sequence similarities

Belongs to the selectin/LECAM family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    549
  • Mass (Da)
    60,080
  • Last updated
    1996-02-01 v1
  • Checksum
    85CEECDB7B0144C8
MNASCFLSALTFVLLIGKSIAWYYNASSELMTYDEASAYCQRDYTHLVAIQNKEEINYLNSTLRYSPSYYWIGIRKVNNVWIWVGTQKPLTEEAKNWAPGEPNNKQRNEDCVEIYIQRPKDSGMWNDERCDKKKLALCYTASCTNTSCSGHGECVETINSYTCKCHPGFLGPKCDQVVTCQEQEYPDHGSLNCTHPFGLFSYNSSCSFSCERGYVPSSMETTVRCTSSGEWSAPAPACHVVECKALTQPAHGVRKCSSNPGSYPWNTTCTFDCEEGYRRVGAQNLQCTSSGVWDNEKPSCKAVTCDAIPRPQNGSVSCSNSTAGALAFKSSCNFTCEHSFTLQGPAQVECSAQGQWTPQIPVCKASQCEALSAPQRGHMKCLPSASAPFQSGSSCKFSCDEGFELKGSRRLQCGPRGEWDSEKPTCAGVQCSSLDLPGKMNMSCSGPAVFGTVCEFTCPEGWTLNGSSILTCGATGRWSAMLPTCEAPANPPRPLVVALSVAATSLLTLSSLIYVLKRFFWKKAKKFVPASSCQSLQSFENYQGPSYII

Computationally mapped potential isoform sequences

There are 3 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AP16A0A8I6AP16_RATSele545
A0A8L2R0D5A0A8L2R0D5_RATSele519
A0A0H2UHU5A0A0H2UHU5_RATSele619

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
L25527
EMBL· GenBank· DDBJ
AAA41113.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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