P97808 · FXYD5_MOUSE

  • Protein
    FXYD domain-containing ion transport regulator 5
  • Gene
    Fxyd5
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane (PubMed:16148001, PubMed:17881459).
May increase NKA activity by increasing the apparent affinity for Na+ (PubMed:17881459).
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentbasolateral plasma membrane
Cellular Componentplasma membrane
Molecular Functionion channel regulator activity
Molecular Functionpotassium channel regulator activity
Molecular Functionsodium channel regulator activity
Biological Processpotassium ion transport
Biological Processregulation of monoatomic ion transport
Biological Processsodium ion transport

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    FXYD domain-containing ion transport regulator 5
  • Alternative names
    • EF-8
    • Ion channel homolog RIC
    • Oncoprotein-induced protein 2

Gene names

    • Name
      Fxyd5
    • Synonyms
      Oit2

Organism names

  • Taxonomic identifier
  • Strains
    • BALB/cJ
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    P97808
  • Secondary accessions
    • Q3TDW1

Proteomes

Organism-specific databases

Subcellular Location

Cell membrane
; Single-pass type I membrane protein
Basolateral cell membrane
; Single-pass type I membrane protein
Note: In kidneys localizes to the basolateral membrane of the connecting tubule.

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain22-145Extracellular
Transmembrane146-166Helical
Topological domain167-178Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain.

Type
IDPosition(s)Description
Signal1-21
ChainPRO_000038899622-178FXYD domain-containing ion transport regulator 5

Post-translational modification

Glycosylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed mainly in epithelial tissue, such as lung, intestine and kidney. Not detected in brain, liver, muscle, and heart.

Developmental stage

Exhibits biphasic expression during development.

Gene expression databases

Interaction

Subunit

Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit. The regulatory subunit, a member of the FXYD protein family, modulates the enzymatic activity in a tissue- and isoform-specific way by changing affinities of the Na+/K+-ATPase toward Na+, K+ or ATP.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region, compositional bias.

Type
IDPosition(s)Description
Region21-130Disordered
Compositional bias22-103Polar residues

Sequence similarities

Belongs to the FXYD family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    178
  • Mass (Da)
    19,454
  • Last updated
    2009-11-24 v3
  • Checksum
    466FBF1E05D861C5
MSLSSRLCLLTIVALILPSRGQTPKKPTSIFTADQTSATTRDNVPDPDQTSPGVQTTPLIWTREEATGSQTAAQTETQQLTKMATSNPVSDPGPHTSSKKGTPAVSRIEPLSPSKNFMPPSYIEHPLDSNENNPFYYDDTTLRKRGLLVAAVLFITGIIILTSGKCRQLSQFCLNRHR

Computationally mapped potential isoform sequences

There are 6 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0J9YUX0A0A0J9YUX0_MOUSEFxyd5108
F8WJA1F8WJA1_MOUSEFxyd5179
F6TWM7F6TWM7_MOUSEFxyd5127
E0CYX7E0CYX7_MOUSEFxyd5111
E0CXM5E0CXM5_MOUSEFxyd5117
E0CXN1E0CXN1_MOUSEFxyd5185

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias22-103Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
U72680
EMBL· GenBank· DDBJ
AAB51040.1
EMBL· GenBank· DDBJ
mRNA
AK003068
EMBL· GenBank· DDBJ
BAB22545.1
EMBL· GenBank· DDBJ
mRNA
AK155763
EMBL· GenBank· DDBJ
BAE33425.1
EMBL· GenBank· DDBJ
mRNA
AK169966
EMBL· GenBank· DDBJ
BAE41487.1
EMBL· GenBank· DDBJ
mRNA
AK170810
EMBL· GenBank· DDBJ
BAE42043.1
EMBL· GenBank· DDBJ
mRNA
AC149055
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp