P97808 · FXYD5_MOUSE
- ProteinFXYD domain-containing ion transport regulator 5
- GeneFxyd5
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids178 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Associates with and regulates the activity of the sodium/potassium-transporting ATPase (NKA) which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane (PubMed:16148001, PubMed:17881459).
May increase NKA activity by increasing the apparent affinity for Na+ (PubMed:17881459).
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity).
May increase NKA activity by increasing the apparent affinity for Na+ (PubMed:17881459).
Involved in down-regulation of E-cadherin which results in reduced cell adhesion. Promotes metastasis (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | basolateral plasma membrane | |
Cellular Component | plasma membrane | |
Molecular Function | ion channel regulator activity | |
Molecular Function | potassium channel regulator activity | |
Molecular Function | sodium channel regulator activity | |
Biological Process | potassium ion transport | |
Biological Process | regulation of monoatomic ion transport | |
Biological Process | sodium ion transport |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameFXYD domain-containing ion transport regulator 5
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionP97808
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Single-pass type I membrane protein
Basolateral cell membrane ; Single-pass type I membrane protein
Note: In kidneys localizes to the basolateral membrane of the connecting tubule.
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 22-145 | Extracellular | |||
Transmembrane | 146-166 | Helical | |||
Topological domain | 167-178 | Cytoplasmic | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-21 | ||||
Chain | PRO_0000388996 | 22-178 | FXYD domain-containing ion transport regulator 5 | ||
Post-translational modification
Glycosylated.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed mainly in epithelial tissue, such as lung, intestine and kidney. Not detected in brain, liver, muscle, and heart.
Developmental stage
Exhibits biphasic expression during development.
Gene expression databases
Interaction
Subunit
Regulatory subunit of the sodium/potassium-transporting ATPase which is composed of a catalytic alpha subunit, a non-catalytic beta subunit and an additional regulatory subunit. The regulatory subunit, a member of the FXYD protein family, modulates the enzymatic activity in a tissue- and isoform-specific way by changing affinities of the Na+/K+-ATPase toward Na+, K+ or ATP.
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 21-130 | Disordered | |||
Compositional bias | 22-103 | Polar residues | |||
Sequence similarities
Belongs to the FXYD family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length178
- Mass (Da)19,454
- Last updated2009-11-24 v3
- Checksum466FBF1E05D861C5
Computationally mapped potential isoform sequences
There are 6 potential isoforms mapped to this entry
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 22-103 | Polar residues | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
U72680 EMBL· GenBank· DDBJ | AAB51040.1 EMBL· GenBank· DDBJ | mRNA | ||
AK003068 EMBL· GenBank· DDBJ | BAB22545.1 EMBL· GenBank· DDBJ | mRNA | ||
AK155763 EMBL· GenBank· DDBJ | BAE33425.1 EMBL· GenBank· DDBJ | mRNA | ||
AK169966 EMBL· GenBank· DDBJ | BAE41487.1 EMBL· GenBank· DDBJ | mRNA | ||
AK170810 EMBL· GenBank· DDBJ | BAE42043.1 EMBL· GenBank· DDBJ | mRNA | ||
AC149055 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. |